DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Pdlim5

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_006501801.1	Gene:	Pdlim5 / 56376	MGIID:	1927489	Length:	734	Species:	Mus musculus

Alignment Length:	621	Identity:	141/621 - (22%)
Similarity:	215/621 - (34%)	Gaps:	159/621 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DTGSPLVCIGHGKVAKLVAKISNNQNASVKRR---------------LDIPPK-PPIKYNEMPQV 65
            :||.|.|.:........|...|..:.|..:||               :.|||| ||.|:
Mouse   195 NTGKPAVNVPRQPTVTSVCSESAQELAEGQRRGSQGDIKQQNGNPGTVKIPPKRPPRKH------ 253

  Fly    66 PSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNPA----ILEQ- 125
                              |....|...|:|.....|.:..:.||:..|..|....:    ||.|
Mouse   254 ------------------IVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI 300

  Fly   126 -QLEALAYHKLQMEKKGLLGVQAKPTQPL-NSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTD 188
             ..|.|...:....||...  .:....|| |....|.:..|.|  ::|.:..|.||
Mouse   301 TGTEHLTESENDNTKKAKF--YSSLEDPLKNGPHPPAAPQLLK--VHSQVAIVSKE--------- 352

  Fly   189 ETKISASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSYSELRHATL 253
                 |:|||:|:.     |..:.:..|....||      ....||....:.|.|..:....|.|
Mouse   353 -----AATYSSVSR-----STRTVEGALEGFGNF------PAFSPPTRYSAVVVSDAAATVSAAL 401

  Fly   254 EFNKPIDYLQNNQ--------TTNPLQIYANQYAMQHDATG-----KSSSTYDSIYEPI------ 299
            .....:...:|:|        :|.|..:..:......:::|     |||||.:...:|.
Mouse   402 AAKTRLFGPENSQSLLDALCISTVPKPLALSCLQSSEESSGSVHVKKSSSTQEPSQQPASSGASP 466

  Fly   300 -----------NPRPCVADTLPRESYN-LHNSYVND---NNPNISHEYNISNSIEANQTLYIHGN 349
                       :.||.||......::. :.::.|..   ..||.:          |..|..|..|
Mouse   467 LSASEGPESPGSSRPSVAGLRSAAAFKPVGSTSVKSPSWQRPNQA----------APSTGRISNN 521

  Fly   350 ART--TFYDVNSIHRNDKEGLKNYISIPTEPVQELENY--GR----CVKCNSRVLGESSGCTAMD 406
            ||:  |...|.....:|::.|          ||..|:.  |:    |..||..:.|..  ..|:.
Mouse   522 ARSSGTGASVGPPQPSDQDTL----------VQRAEHIPAGKRTPMCAHCNQVIRGPF--LVALG 574

  Fly   407 QIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEK-----CSVCMEPILERILRATGKP 466
            :.:|...|.|..|:..:....|....|..|||..|    ||     |..|...||..::.|..:.
Mouse   575 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCY----EKFFAPECGRCQRKILGEVINALKQT 635

  Fly   467 YHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALD 531
            :|..||.||.|||.:...:|.:: ..:.||.||::..|...|..|:.||     :...:.:.||.
Mouse   636 WHVSCFVCVACGKPIRNNVFHLE-DGEPYCETDYYALFGTICRGCEFPI-----EAGDMFLEALG 694

  Fly   532 RSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCK 567
            .::|..|:.|..|    ....||:..:...|..|||
Mouse   695 YTWHDTCFVCSVC----CESLEGQTFFSKKDKPLCK 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/52 (27%)
		LIM2_LPP	448..507	CDD:188740	19/58 (33%)
		LIM3_LPP	508..575	CDD:188821	16/60 (27%)
Pdlim5	XP_006501801.1	PDZ_signaling	10..82	CDD:238492
		PHA03307	150..>540	CDD:223039	84/407 (21%)
		DUF4749	214..315	CDD:374237	25/124 (20%)
		LIM1_ENH	558..609	CDD:188837	14/52 (27%)
		LIM2_ENH	617..668	CDD:188841	17/51 (33%)
		LIM3_ENH	676..730	CDD:188843	16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910