DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and LIMS2

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_060450.2	Gene:	LIMS2 / 55679	HGNCID:	16084	Length:	365	Species:	Homo sapiens

Alignment Length:	220	Identity:	58/220 - (26%)
Similarity:	91/220 - (41%)	Gaps:	35/220 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEK-CSVC 451
            |.:|.:|.........:..::||..||.|..|........||..:|:.|||:|:...... |..|
Human    39 CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSC 103

  Fly   452 MEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYC--------ITDFHKKFAPRC 508
            .|.|:.|:::|....:||.||.|.:|...|..|.|..:| .::.|        .....|....||
Human   104 GEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNA-GRHLCRPCHNREKAKGLGKYICQRC 167

  Fly   509 --CVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEA-EGRG---CYPLDDHV--- 564
              .:.:||:|            ....::|.:.:.|..||..|::|| |.:|   |.|..|.:
Human   168 HLVIDEQPLM------------FRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVP 220

  Fly   565 LCKSC----NAKRVQALTNRMTSEH 585
            :|.:|    ..:.|.||..:...||
Human   221 ICGACRRPIEGRVVNALGKQWHVEH 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	15/52 (29%)
		LIM2_LPP	448..507	CDD:188740	18/66 (27%)
		LIM3_LPP	508..575	CDD:188821	18/79 (23%)
LIMS2	NP_060450.2	LIM1_PINCH	39..97	CDD:188717	16/57 (28%)
		LIM2_PINCH	100..151	CDD:188718	17/51 (33%)
		LIM3_PINCH	164..214	CDD:188719	16/61 (26%)
		LIM4_PINCH	220..273	CDD:188720	7/26 (27%)
		LIM5_PINCH	281..334	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810