DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and lmo7a

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_021334325.1	Gene:	lmo7a / 553341	ZFINID:	ZDB-GENE-030219-74	Length:	1893	Species:	Danio rerio

Alignment Length:	378	Identity:	68/378 - (17%)
Similarity:	127/378 - (33%)	Gaps:	87/378 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 KLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTDETKISASTYS 198
            |.|:|:|..|..:.:..:......:...|...:..:.......|:| |..:...::.|:.:..|:
Zfish  1526 KKQIEEKQRLEEERRRREEQQRLEELRRKREEEQRLLQEKERNRRE-EEKKRFQEQDKVDSFCYT 1589

  Fly   199 NVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSYSELRHATLE--------F 255
            || ...:..||.|..|         |..|.||:     .::.:...|.  ||..|.        .
Zfish  1590 NV-YPELSYSHRSISK---------STPELDEV-----AKTDIKGVYG--RHRGLAGWLLEEELR 1637

  Fly   256 NKPIDYLQNNQTTNPLQIYANQY--AMQHDATGKSSSTYDSIYEPINPRPCVADTLPRE------ 312
            .|....:|..|..:.|::.....  ||::....::|.....:.......|.....|.|:
Zfish  1638 RKKNPQMQRKQAASELELERRSILNAMKYRNPERASGGLSEVNRDYQKEPLTQSELERQQILQEM 1702

  Fly   313 ----SYNLHNSYVNDNNPNISHEYNISNSIEANQTL-------------YIHGNARTTFYDVNSI 360
                |.|..||::..:..::..:..|...|...::|             :...|:.::..|.:..
Zfish  1703 RKKTSLNTDNSWIRQSTSSVPAKEPIDLPIRRGESLDNLDEPRSSWRSSWSTSNSTSSIPDYSRP 1767

  Fly   361 H---------------------RNDKEGLKNYISIPTEPVQ------ELENYGR--CVKCNSRVL 396
            |                     ......|:...|.|..|.:      .....||  |..|:: .|
Zfish  1768 HSALSGSTLQPAGRPGSATMQASQSMSSLRQSTSTPANPPEPRAPQRNRSVSGRKICSFCDT-PL 1831

  Fly   397 GESSG--CTAMDQIYHIFCFTCTDCQINLQGKPFYA----LDGKPYCEYDYLQ 443
            |:.:.  ..::...||:.||.|:||:.:|.|....|    .:.:.||...|::
Zfish  1832 GKGAAMIIESLGLCYHLTCFKCSDCRSDLGGSQAGAEVRIRNQQLYCNVCYMR 1884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	16/58 (28%)
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
lmo7a	XP_021334325.1	CH	17..128	CDD:237981
		DUF4757	239..>311	CDD:318215
		DUF4757	733..881	CDD:318215
		TOP2c	<809..1096	CDD:330395
		PDZ	1184..1245	CDD:238080
		Neuromodulin_N	<1396..1506	CDD:331332
		LIM	1824..1882	CDD:259829	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900