DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and PAX3

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_852124.1	Gene:	PAX3 / 5077	HGNCID:	8617	Length:	505	Species:	Homo sapiens

Alignment Length:	459	Identity:	83/459 - (18%)
Similarity:	139/459 - (30%)	Gaps:	172/459 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VAQQLRELSLPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPKPPIKYNEMPQVPSS 68
            :::|||               :.||.|:|::.:.  .:..|::.......||  |....|.|...
Human    72 ISRQLR---------------VSHGCVSKILCRY--QETGSIRPGAIGGSKP--KQVTTPDVEKK 117

  Fly    69 ---------------------RQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQ-- 110
                                 :..:|.|..:.|...|.            :.|.|:||..:.:
Human   118 IEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSIS------------RILRSKFGKGEEEEA 170

  Fly   111 -INRKTTLDNPAILEQQLEALAYHKLQMEKKGLLG-------------VQAKPTQPL-------- 153
             :.||..        ::.|..|.|.:.    |:|.             :.::|..||
Human   171 DLERKEA--------EESEKKAKHSID----GILSERASAPQSDEGSDIDSEPDLPLKRKQRRSR 223

  Fly   154 NSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTDETKISAST----YSN----------VNE-- 202
            .:||....:.|.::...::.    .:|.|.|.|....|::.:.    :||          .|:
Human   224 TTFTAEQLEELERAFERTHY----PDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLM 284

  Fly   203 ------------TAMDS----SHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSYSELRHA 251
                        |||.:    ..|.|....:.....:||.......|.|.|.|.|.
Human   285 AFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVH--------- 340

  Fly   252 TLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPINP----RPCVADTLPRE 312
                       |:...:||..  ::.|.:.....|.||.| ||...|..|    .|.:.:.|..:
Human   341 -----------QSTIPSNPDS--SSAYCLPSTRHGFSSYT-DSFVPPSGPSNPMNPTIGNGLSPQ 391

  Fly   313 SYNLHNSYVNDNNPNISHEYNISNSIEANQTLY-----IHGNARTTFYDVNSIHRNDKEGLKNYI 372
            ...|..     |:..:.|:         .||.|     ..|...||....:...|.|.  :|:..
Human   392 VMGLLT-----NHGGVPHQ---------PQTDYALSPLTGGLEPTTTVSASCSQRLDH--MKSLD 440

  Fly   373 SIPT 376
            |:||
Human   441 SLPT 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:128645	17/117 (15%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93		7/37 (19%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		6/59 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		11/74 (15%)
		Homeobox	222..276	CDD:395001	10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		11/63 (17%)
		Pax7	347..391	CDD:403540	13/46 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910