DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and smash

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	88/466 - (18%)
Similarity:	159/466 - (34%)	Gaps:	142/466 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AKISNNQNASVKRRLDIPPKPPIKYNEMPQVPSSRQVLCSREPLYSQ-PLIGVEKTMRGHMPFRK 98
            |...|...|......|:.|.|   ....|.:|:.:|.|  ::|..:| |...|.:.  ...|.|
  Fly   563 ANAVNQIEAEFDELTDLHPSP---LPPSPALPAVQQSL--QQPTVAQVPAQAVNQA--AAPPLR- 619

  Fly    99 YLSSEFGVADTQINRKTTLDNPAILEQQLEAL-----------AYHKLQMEKKGLLGVQAKPTQP 152
              ..||.:.:.             ||..|:|:           |.|..:.|:|..||.:.:..:|
  Fly   620 --DMEFSINEA-------------LELALQAIDREATTKPMDKAQHPQKREQKEELGGKPEEKEP 669

  Fly   153 L----------------NSFTKPLSKTLSKSL------IYSNLGSV-------RKEIETLELL-- 186
            :                |...:..:|| .|.:      ||.|:.|.       .::|.|:.:.
  Fly   670 ICEEQHDEESNEQGETHNEGGEMPNKT-DKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQ 733

  Fly   187 TDETKIS---------ASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVS 242
            |..|:||         .|..:..|::...:|:|..||..|......::      |.||:.....:
  Fly   734 TQATRISHRRSIPSQQTSNSNENNQSTNQTSNSRNQKESSTAATSAAN------PVPPTTPGEQA 792

  Fly   243 SSYSELRHATLEFNKPIDYLQNNQTTNPLQIYANQ---YAMQHDATGKSSSTYDSIYEPIN---P 301
            ..|.::..||    :|  |....:...|:.:|.|.   |:....:.|...:.. .:.||..   |
  Fly   793 EPYYQVPKAT----EP--YYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPV-GLMEPPKEKPP 850

  Fly   302 RPCVADTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQTL------YIHG------------ 348
            .|.....:|.:..  |:..::....::.|..:..:|....:|:      ::.|
  Fly   851 PPPTESPIPLDEG--HDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIK 913

  Fly   349 -------------NARTTFYDVNSIHRNDKEGLKNYISI----PTEPVQELENYGRCVK------ 390
                         |.|::|..:.  :..|.:.::.|:.:    |.:..|.|:...|..|
  Fly   914 RMNSTKRIKKELRNKRSSFLGIE--NDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYIKA 976

  Fly   391 --CNSRVLGES 399
              |:|...|||
  Fly   977 GLCDSSDTGES 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	6/20 (30%)
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900