Protein Alignment Zyx and LPP

DIOPT Version :9

• Sequence 1: NP_652015.1
• Gene: Zyx / 317824
• FlyBaseID: FBgn0011642
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_011511125.1
• Gene: LPP / 4026
• HGNCID: 6679
• Length: 637
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 207/644 - (32%)
• Similarity: 292/644 - (45%)
• Gaps: 111/644 - (17%)

  Fly    13 LPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPK-------PPIKYNEMPQVPSSRQ 70
            ||...||.||     |.|...:....:..|.|:......|||       |..|||...|......
Human    32 LPPKSTGEPL-----GHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGD 91

  Fly    71 VLCSREPLYSQPL--IGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNPAILEQQLEALAYH 133
            .|....|    ||  .....::.|:.|....|..|..........||..:..:.|:.::::|...
Human    92 FLPPPPP----PLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSI 152

  Fly   134 KLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLS------KSLIYSN---LGSVRKE---------- 179
            ...:|    .....||..|.:|.....|..:|      |.::..|   |.:.:|.
Human   153 LADLE----CSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQA 213

  Fly   180 -------IETLELLTDETKISASTYSNVNETAMD----SSHSSTQKMLSVCTNFISDN-----EK 228
                   |.||:........|.:|.|..:....:    |:..|...|.:..:..|..:     ..
Human   214 GPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNT 278

  Fly   229 DELP-----PPPSPESAVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKS 288
            ..:|     ||||....:  .|:.:....|:......|..|..     :.|...||......|::
Human   279 QPVPVSGQCPPPSTRGGM--DYAYIPPPGLQPEPGYGYAPNQG-----RYYEGYYAAGPGYGGRN 336

  Fly   289 SSTYDSIY-----------EPINPRPCVADTLPRESYNL---HNSYVNDN---------NPNISH 330
            .|  |..|           ||....|...:..|...|.:   ..:|:.|.         .|...|
Human   337 DS--DPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGH 399

  Fly   331 EYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPVQELENYGRCVKCNSRV 395
            ...:..|           :...:|...:.:....|:.|.:..:.|.:     |.:|||.:|...|
Human   400 SGQLGPS-----------SVAPSFRPEDELEHLTKKMLYDMENPPAD-----EYFGRCARCGENV 448

  Fly   396 LGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEKCSVCMEPILERIL 460
            :||.:|||||||::|:.||||..|...|:|:||||::.|.|||..|:.|||:|:||.:||:||||
Human   449 VGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERIL 513

  Fly   461 RATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETI 525
            |||||.|||.|||||:|.:||||:.|||||....:||.||||||||||.|||:||||.||||||:
Human   514 RATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETV 578

  Fly   526 RVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQALTNRMTSE 584
            |:|||||.||:.||:|||||.|| ||.:.:||||||.|:|||:||:.|::.||.:.:::
Human   579 RIVALDRDFHVHCYRCEDCGGLL-SEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTD 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	28/52 (54%)
		LIM2_LPP	448..507	CDD:188740	41/58 (71%)
		LIM3_LPP	508..575	CDD:188821	46/66 (70%)
LPP	XP_011511125.1	WWbp	<229..316	CDD:304964	15/88 (17%)
		LIM1_TRIP6	441..494	CDD:188736	28/52 (54%)
		LIM2_TRIP6	501..553	CDD:188742	34/51 (67%)
		LIM3_TRIP6	561..626	CDD:188820	45/65 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7547
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001663
OrthoInspector	1	1.000	-	-		otm40409
orthoMCL	1	0.900	-	-		OOG6_108119
Panther	1	1.100	-	-	LDO	PTHR24207
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3402
SonicParanoid	1	1.000	-	-		X2600
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.940