DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and LMO7

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_024305122.1	Gene:	LMO7 / 4008	HGNCID:	6646	Length:	1727	Species:	Homo sapiens

Alignment Length:	477	Identity:	92/477 - (19%)
Similarity:	156/477 - (32%)	Gaps:	138/477 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PKPPIKYNEMPQVPSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTL 117
            |:..:.:.:..:.|.. |::..||..:.|.|...::        :|.|.:|   |:.|.......
Human  1353 PQEEVVHEDQGKKPQD-QLVIERERKWEQQLQEEQE--------QKRLQAE---AEEQKRPAEEQ 1405

  Fly   118 DNPAILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIET 182
            ...|.:|::.....|               :..:|::|:..|.::..|...:   .|...|...|
Human  1406 KRQAEIERETSVRIY---------------QYRRPVDSYDIPKTEEASSGFL---PGDRNKSRST 1452

  Fly   183 LELLTDETKISASTYSNVNETAMD--SSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSY 245
            .||  |:    .||..|.|...:|  .:.:|:|:.          ::|:::|           |.
Human  1453 TEL--DD----YSTNKNGNNKYLDQIGNMTSSQRR----------SKKEQVP-----------SG 1490

  Fly   246 SELRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVADTLP 310
            :||....:        ||..:...||. ..|.:..|..|:             :|..|.....:.
Human  1491 AELERQQI--------LQEMRKRTPLH-NDNSWIRQRSAS-------------VNKEPVSLPGIM 1533

  Fly   311 RESYNLHNSYVNDNNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIP 375
            |...:|.|.    ::|.       |||......|    |..|.||..:|:.           ...
Human  1534 RRGESLDNL----DSPR-------SNSWRQPPWL----NQPTGFYASSSVQ-----------DFS 1572

  Fly   376 TEPVQELENYGRCVKCN--SRVLGESSG---------CTAMDQIYHIFCFTCTDCQINLQGKPFY 429
            ..|.|.:....|....|  |.|...|:|         .|...........:.:.....|:.:
Human  1573 RPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNR--- 1634

  Fly   430 ALDGKPYCEYDYLQTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDA---T 491
            ::.||..|.|        |:..:......|:.:.|..||..||.||.|...|.|.....:.   .
Human  1635 SVSGKRICSY--------CNNILGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIRN 1691

  Fly   492 NQNYCITDFHKKFAPRCCVCKQ 513
            :|.|| .|.:.:|.     ||:
Human  1692 HQLYC-NDCYLRFK-----CKR 1707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	11/63 (17%)
		LIM2_LPP	448..507	CDD:188740	17/61 (28%)
		LIM3_LPP	508..575	CDD:188821	2/6 (33%)
LMO7	XP_024305122.1	DUF4757	213..>263	CDD:318215
		DUF4757	627..774	CDD:318215
		PDZ	1042..1109	CDD:238080
		GBP_C	<1255..1311	CDD:328214
		Neuromodulin_N	<1256..1414	CDD:331332	14/72 (19%)
		coiled coil	1298..1309	CDD:293879
		LIM	1642..1700	CDD:259829	18/66 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900