DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and fhl1a

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001007288.1	Gene:	fhl1a / 399646	ZFINID:	ZDB-GENE-040206-1	Length:	297	Species:	Danio rerio

Alignment Length:	239	Identity:	68/239 - (28%)
Similarity:	104/239 - (43%)	Gaps:	33/239 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 DVNSIHRNDKEG----LKNYISIPTEPVQELENYGR--CVKCNSR-----------VLGESSGCT 403
            ::|..:|:..||    .|.|..:..||.|..:: |:  |.||..|           |:  :.||.
Zfish    69 ELNHKNRHWHEGCFRCAKCYKPLANEPFQAKDD-GKIMCGKCGDRDGSPRCQGCYKVI--TPGCK 130

  Fly   404 AMD---QIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEK-CSVCMEPILERILRATG 464
            .::   :::|..||||.:|:..::.:.|.......||...:.:...| |..|.|.|....|....
Zfish   131 NVEYKHKVWHEECFTCFECKQPIRTQSFLTKGDDMYCTPCHEKKFAKHCVRCKEAITSGGLTYQD 195

  Fly   465 KPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVA 529
            :|:|.:||.|..|.|.|.|..||.. .:|.||:..:....|.:|..|:.||   .|......||.
Zfish   196 QPWHSECFVCHTCKKPLAGARFTAH-EDQFYCVDCYKSDVAKKCSGCQNPI---TGFGRGTNVVN 256

  Fly   530 L-DRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAK 572
            . |:|:|..|:.|:.|.|   |.|..|.....:| :.|..|..|
Zfish   257 YEDKSWHEYCFNCKKCSL---SMAHKRFVINGED-IYCSDCAKK 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	16/66 (24%)
		LIM2_LPP	448..507	CDD:188740	20/58 (34%)
		LIM3_LPP	508..575	CDD:188821	21/66 (32%)
fhl1a	NP_001007288.1	LIM	<21..49	CDD:295319
		LIM1_FHL1	56..110	CDD:188730	12/41 (29%)
		LIM2_FHL1	118..175	CDD:188808	12/58 (21%)
		LIM3_FHL1	179..231	CDD:188813	19/52 (37%)
		LIM4_FHL1	234..297	CDD:188734	22/70 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810