DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and LIMS1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001358423.1	Gene:	LIMS1 / 3987	HGNCID:	6616	Length:	398	Species:	Homo sapiens

Alignment Length:	318	Identity:	73/318 - (22%)
Similarity:	121/318 - (38%)	Gaps:	81/318 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 RPCVA---DTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQTLY-IHGNART-----TFYDV 357
            |||:.   :.:||.:.            |..||.|.:....|...|. .|.:.:.     .||
Human     8 RPCIIPENEEIPRAAL------------NTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFY-- 58

  Fly   358 NSIHRNDKEGLKNYISIPTEPVQELENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQIN 422
                  .|..:.|.::..|           |.:|............:..::||..||.|..|...
Human    59 ------AKFNMANALASAT-----------CERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQ 106

  Fly   423 LQGKPFYALDGKPYCEYDYLQTLEK-CSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLF 486
            .....||..:|:.|||:|:...... |..|.|.|:.|:::|....:||:||.|.:|.:.|..:.|
Human   107 FPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGF 171

  Fly   487 TVDATNQNYCITDFHKKFAPR------CCVC-----KQPIM--PDPGQEETIRVVALDRSFHLEC 538
            ..:| .::.| ...|.:...|      |..|     :||::  .||              :|.:.
Human   172 VKNA-GRHLC-RPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDP--------------YHPDH 220

  Fly   539 YKCEDCGLLLSSEA-EGRG---CYPLDDHV---LCKSC----NAKRVQALTNRMTSEH 585
            :.|.:||..|:::| |.:|   |.|..|.:   :|.:|    ..:.|.|:..:...||
Human   221 FNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEH 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/52 (27%)
		LIM2_LPP	448..507	CDD:188740	17/58 (29%)
		LIM3_LPP	508..575	CDD:188821	19/84 (23%)
LIMS1	NP_001358423.1	LIM1_PINCH	72..130	CDD:188717	15/57 (26%)
		LIM2_PINCH	133..184	CDD:188718	16/52 (31%)
		LIM3_PINCH	197..247	CDD:188719	16/63 (25%)
		LIM4_PINCH	253..306	CDD:188720	6/26 (23%)
		LIM5_PINCH	314..367	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910