DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and LIMK2

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001026971.1	Gene:	LIMK2 / 3985	HGNCID:	6614	Length:	686	Species:	Homo sapiens

Alignment Length:	85	Identity:	28/85 - (32%)
Similarity:	39/85 - (45%)	Gaps:	3/85 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 FTCTDCQINLQGKPFYALDGKPYCEYDYLQTL-EKCSVCMEPILERILRATGKPYHPQCFTCVVC 477
            |.|::||.:|... :|..|||.||..||.... |.|..|...:....:.|....|||:||.|:.|
Human    17 FRCSECQDSLTNW-YYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSC 80

  Fly   478 GKSL-DGLLFTVDATNQNYC 496
            ...: ||..:.:......||
Human    81 KVIIEDGDAYALVQHATLYC 100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	11/26 (42%)
		LIM2_LPP	448..507	CDD:188740	14/50 (28%)
		LIM3_LPP	508..575	CDD:188821
LIMK2	NP_001026971.1	LIM	<15..44	CDD:295319	12/27 (44%)
		LIM2_LIMK2	46..104	CDD:188849	15/55 (27%)
		PDZ	131..215	CDD:278991
		PKc_like	316..570	CDD:328722
		PP1_inhibitor	564..686	CDD:283108
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910