DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and LIMK1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_002305.1	Gene:	LIMK1 / 3984	HGNCID:	6613	Length:	647	Species:	Homo sapiens

Alignment Length:	154	Identity:	47/154 - (30%)
Similarity:	78/154 - (50%)	Gaps:	11/154 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTL-EKCSVC 451
            |..|..|:. :.....|::..:|..||.|.||..:|..: :|..||:.:|:.||.... |.|..|
Human    25 CASCGQRIY-DGQYLQALNADWHADCFRCCDCSASLSHQ-YYEKDGQLFCKKDYWARYGESCHGC 87

  Fly   452 MEPILERILRATGK-PYHPQCFTCVVCGKSL-DGLLFTVDATNQNYCITDFHKKFAPRCCVCKQP 514
            .|.|.:.::...|: .|||:||.|:.||..: ||..:|:...::.||...:::.....  |.:|
Human    88 SEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTP--VIEQ- 149

  Fly   515 IMPD-PGQE--ETIRVVALDRSFH 535
            |:|| ||..  .|:.:|::..|.|
Human   150 ILPDSPGSHLPHTVTLVSIPASSH 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	15/52 (29%)
		LIM2_LPP	448..507	CDD:188740	18/60 (30%)
		LIM3_LPP	508..575	CDD:188821	11/31 (35%)
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	16/53 (30%)
		LIM	84..138	CDD:295319	18/53 (34%)
		PDZ	165..255	CDD:278991	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..319
		STKc_LIMK1	345..611	CDD:271123
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910