DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and pdlim1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_017950803.1	Gene:	pdlim1 / 394527	XenbaseID:	XB-GENE-1004691	Length:	345	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	89/427 - (20%)
Similarity:	151/427 - (35%)	Gaps:	129/427 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SSRQVLCSREPLYSQPLIGVEK-----TMRGHMPFRKYLSSEFGVADTQINRKTTLDNPAILEQQ 126
            ::::::.:..|.:...|||.:.     |:...||..|...::..:.|..|    ::|.     :.
Frog     2 ATKRIVMTAPPPWGFRLIGGKDFDQPLTISRVMPGSKAAVADLCIGDVVI----SIDG-----EN 57

  Fly   127 LEALAYHKLQMEKKG--------LLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETL 183
            .:.:.:.:.|.:.||        :..|::|...||      :|:....:....||.|..:|::.:
Frog    58 TDGMTHLEAQNKIKGCEDELILTINRVESKIWSPL------VSEDGKPNPYKMNLASNPQELKQI 116

  Fly   184 ELLTDETKISASTYSNVNETAMDSSHSSTQKMLSVCTN-----FISDNEKD---ELPPPPSPESA 240
            .        ||...|.:..||  :|.|||.|:::...|     :.|||.::   .|....:|.:.
Frog   117 G--------SAHNRSAMPFTA--ASASSTPKVITAQYNNPAGLYSSDNIENFNSALETKSTPSAQ 171

  Fly   241 VSSSYSE------LRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPI 299
            |.|..||      .||...| ::....||.||                           .:.||
Frog   172 VPSKASEPTQPANTRHLDKE-SEVYKMLQENQ---------------------------ELDEP- 207

  Fly   300 NPRPCVADTLPRESYN---LHNSYVNDNNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIH 361
                      ||:|.:   |......|           ....|..:.||. |.....|.|..
Frog   208 ----------PRQSASFLVLQEILETD-----------EKDFEGTECLYT-GPMERPFIDAG--- 247

  Fly   362 RNDKEGLKNYISIPTEPVQELENYGR----CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQIN 422
             ....|.:: :..||..|......|:    |..|.|.::|..  ....|:.:|..|:.||||.:|
Frog   248 -EKPSGFRS-VRAPTTKVAASLGSGQKLPICGHCGSGIVGVF--VKIRDKPHHPECYVCTDCGMN 308

  Fly   423 LQGKPFYALDGKPYCE------------YDYLQTLEK 447
            |:.|..:.::.|.|||            ||.:....|
Frog   309 LKQKGHFFVEDKMYCEKHARERMTPPEGYDVVTVFPK 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	19/64 (30%)
		LIM2_LPP	448..507	CDD:188740	89/427 (21%)
		LIM3_LPP	508..575	CDD:188821
pdlim1	XP_017950803.1	PDZ_signaling	5..81	CDD:238492	14/84 (17%)
		DUF4749	137..225	CDD:374237	25/137 (18%)
		LIM_CLP36	276..327	CDD:188832	18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910