DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and Tes

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	146/703 - (20%)
Similarity:	230/703 - (32%)	Gaps:	186/703 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESVAQQLRELSLPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVK-------------RRLDIP 52
            ::...|:|||            .|:|.|.|.:|..::::.|...|.             :.|.:.
  Fly   176 LQQYVQKLRE------------QCVGQGVVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGLM 228

  Fly    53 PKPPIKYNEMPQVPSSRQVL---CSREP----LYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQ 110
            |......||:...|...|.|   .|..|    .:|:||  .|.|.:         ..|.|....|
  Fly   229 PVADDTLNELLANPKVAQALASPASAHPKLLVAFSEPL--CESTAQ---------FEENGALRAQ 282

  Fly   111 INRKTT-LDNPAILEQQLEALAYHK---LQMEKKGLLGVQAKP-TQPLNSFTKPLSKTLSKSLIY 170
            ...|.. :..||:|......:.|.|   :..|||  |.:...| ..|:..|.|.          |
  Fly   283 TREKLLGISKPALLSLVTHGIVYDKVLGILQEKK--LNISRDPKLGPIAEFRKE----------Y 335

  Fly   171 SNLGSVRKEIETLELLTDETKI---------SASTYSNVNETAMDSSHSSTQKMLSVCTNFIS-- 224
            .|....|.||.|:......|.|         |.....|..:..|.:.......|..|....:|
  Fly   336 VNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTI 400

  Fly   225 ----------DNEKDELPPPPSPESAVSSSYSELRHATLE--------------FNKPIDYLQNN 265
                      |.::|       |..|.......|:||..|              ...|:..|...
  Fly   401 VYDCGLPANTDYDRD-------PVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAEL 458

  Fly   266 QTTNP-----LQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVADT--LPRESYNLHNSYVND 323
            :..||     ||.......|...|. .::..||.::..::.:....|.  |.:....:|:..::|
  Fly   459 RGLNPATRAQLQSVGLDKNMLQSAV-SNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDD 522

  Fly   324 NN----------------PNISH------EYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKE 366
            :.                .:||:      |...|.|.::.    .|....|..|....:    ..
  Fly   523 DQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSG----FHSKPPTPGYGSEDL----TA 579

  Fly   367 GLKNYISIP--------------TEPVQELENYG------------RCVKCNSRV-LGE---SSG 401
            |...:.|||              .|..|:|..:|            .|..||..: :||   .:.
  Fly   580 GQGRFASIPGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKAD 644

  Fly   402 CTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLE--KCSVCMEPILERILRATG 464
            ....:..:|..||.|..|:..|....::...|:.:|..|....|:  :|..|.|.|..:...|..
  Fly   645 RAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAE 709

  Fly   465 K-PYHPQCFTCVVCGKSLDGLLFTVD-ATNQNYCITDFHKKFAPRCCVCKQPIMP-DPGQEETIR 526
            : .:|.:.|.|..|.:.|.|..:..| .:|...|:..:.:.||.||..||..|.| |.|
  Fly   710 EATFHIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG------ 768

  Fly   527 VVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQALTN 579
            |...|..:|..|:.|  .|:..|....| |.:.:.:::  ..|:...|::|.|
  Fly   769 VAWGDVHWHASCFVC--AGVQCSKPLIG-GRFCVKENM--PFCSPTCVRSLIN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	13/56 (23%)
		LIM2_LPP	448..507	CDD:188740	16/60 (27%)
		LIM3_LPP	508..575	CDD:188821	17/67 (25%)
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	8/32 (25%)
		LIM1_Testin_like	627..684	CDD:188726	13/56 (23%)
		LIM2_Testin_like	691..748	CDD:188727	14/56 (25%)
		LIM	755..810	CDD:295319	17/65 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810