DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and prickle1a

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_899185.2	Gene:	prickle1a / 368249	ZFINID:	ZDB-GENE-030724-5	Length:	793	Species:	Danio rerio

Alignment Length:	345	Identity:	82/345 - (23%)
Similarity:	127/345 - (36%)	Gaps:	62/345 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 LQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVA--DTLPRESYNLHNSYVNDN 324
            |......|.|.:...:.:...|.:|.:...|..:...:.|.....  ..||.:..    .|||..
Zfish     9 LHMGSKVNKLTLGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVALYFSCLPEDKV----PYVNSP 69

  Fly   325 N------------PNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGL-KNYISIPT 376
            .            |...:|.....|:...:...:|         :.||.|. ||.| :..:.|..
Zfish    70 GEKQRIKQLLYQLPPHDNEVRYCQSLSEEEKKELH---------MFSIQRK-KEALGRGTLKILP 124

  Fly   377 EPVQELENYGRCVKCNSRVL-GESSGC----TAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPY 436
            ..|    ::..|..|..|:. ||.:.|    .|..|.:|..||||:.|...|....::..|||.:
Zfish   125 RTV----HHAACEHCGERLSGGEMAVCVSRAAAAGQCWHPACFTCSTCSELLVDLIYFYHDGKVH 185

  Fly   437 CEYDYLQTLE-KCSVCMEPIL-ERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITD 499
            |...:.:.|: :||.|.|.|. :....|.|:.:|.:.|:|..|...|.|..: :....:.:|...
Zfish   186 CGRHHAELLKPRCSSCDEIIFADECTEAEGRHWHMKHFSCSECEVILGGQRY-IMKDGRPFCCGC 249

  Fly   500 FHKKFAPRCCVCKQPIMPDPGQ--EETIRVVALDRSFHLECYKCEDC--GLLLSSEAEGRGC--Y 558
            |...:|..|..|.|.|..|..|  .:.:...|.|     .|:.|..|  .||        ||  .
Zfish   250 FQSLYAEYCQACAQHIGVDHAQMTYDGLHWHATD-----ACFSCAQCKSSLL--------GCPFL 301

  Fly   559 PLDDHVLC-KSCN-AKRVQA 576
            |....:.| |:|: .:.|||
Zfish   302 PRQGRIYCSKACSLGEDVQA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	19/57 (33%)
		LIM2_LPP	448..507	CDD:188740	16/59 (27%)
		LIM3_LPP	508..575	CDD:188821	19/74 (26%)
prickle1a	NP_899185.2	PET_Prickle	28..124	CDD:193602	20/109 (18%)
		LIM1_Prickle	132..191	CDD:188799	19/58 (33%)
		LIM2_Prickle	196..251	CDD:188802	14/55 (25%)
		LIM3_Prickle	256..314	CDD:188804	18/70 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810