DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Limd1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001106208.1	Gene:	Limd1 / 316101	RGDID:	1309830	Length:	663	Species:	Rattus norvegicus

Alignment Length:	196	Identity:	98/196 - (50%)
Similarity:	134/196 - (68%)	Gaps:	6/196 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 YGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYL-----QT 444
            :|.||||:..|.|....|.||..:||..||||..|...|:||.||.::||.:||.|:|     |:
  Rat   456 FGACVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQS 520

  Fly   445 LEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCC 509
            .::|.:|...|::.||:|.||.|||.||.||:|.:.|||:.||||:.|:.||:.|:||..||:|.
  Rat   521 ADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCA 585

  Fly   510 VCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRV 574
            .|..||:|..|.:||||||::||.:|:|||.||||||.|:.| :|..||||:||:.|.||:.||:
  Rat   586 ACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCYPLEDHLFCHSCHVKRL 649

  Fly   575 Q 575
            :
  Rat   650 E 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	25/52 (48%)
		LIM2_LPP	448..507	CDD:188740	30/58 (52%)
		LIM3_LPP	508..575	CDD:188821	38/66 (58%)
Limd1	NP_001106208.1	Mediates nuclear export. /evidence=ECO:0000250	54..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..158
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	180..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..297
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..416
		Interaction with RB1. /evidence=ECO:0000250	391..429
		Necessary for nuclear localization. /evidence=ECO:0000250	459..663		97/193 (50%)
		LIM1_Ajuba_like	459..512	CDD:188738	25/52 (48%)
		LIM2_Ajuba_like	524..576	CDD:188741	26/51 (51%)
		LIM3_Ajuba_like	584..645	CDD:188822	35/61 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810