DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Prickle1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_955428.1	Gene:	Prickle1 / 315259	RGDID:	735090	Length:	831	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	78/348 - (22%)
Similarity:	122/348 - (35%)	Gaps:	89/348 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 PLQIYANQYAMQHDATGKSSSTYDS-------IYEPINPRP--------CVADTLPRESYNLHNS 319
            ||::......:.......|:|..||       .:.|...||        |    ||.|..    .
  Rat     2 PLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFAC----LPEEKV----P 58

  Fly   320 YVNDNNPNISHEYNISNSIEANQTLY---IHGNARTTFYDV---NSIHRNDKEGLKNYISIPTEP 378
            ||  |:|...|        ...|.||   .|.|      :|   .|:...:|:.|:.:     ..
  Rat    59 YV--NSPGEKH--------RIKQLLYQLPPHDN------EVRYCQSLSEEEKKELQVF-----SA 102

  Fly   379 VQELENYGR--------------CVKCNSRVLGESSGCTAM----DQIYHIFCFTCTDCQINLQG 425
            .::.|..||              |.:|..::.|......|.    ...:|..||.|..|...|..
  Rat   103 QRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVD 167

  Fly   426 KPFYALDGKPYCEYDYLQTLE-KCSVCMEPIL-ERILRATGKPYHPQCFTCVVCGKSLDGLLFTV 488
            ..::..|||.:|...:.:.|: :||.|.|.|. :....|.|:.:|.:.|.|:.|...|.|..: :
  Rat   168 LIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRY-I 231

  Fly   489 DATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALD-RSFHL--ECYKCEDCGLLLSS 550
            ....:.:|...|...:|..|..|.:.|..|..|      :..| :.:|.  .|:.|..|
  Rat   232 MKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQ------MTYDGQHWHATEACFSCAQC------ 284

  Fly   551 EAEGRGC--YPLDDHVLC-KSCN 570
            :|...||  .|....:.| |:|:
  Rat   285 KASLLGCPFLPKQGQIYCSKTCS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/56 (25%)
		LIM2_LPP	448..507	CDD:188740	16/59 (27%)
		LIM3_LPP	508..575	CDD:188821	17/69 (25%)
Prickle1	NP_955428.1	PET_Prickle	22..118	CDD:193602	27/124 (22%)
		LIM1_Prickle_1	126..184	CDD:188867	14/57 (25%)
		LIM2_Prickle	189..244	CDD:188802	14/55 (25%)
		LIM3_Prickle	249..307	CDD:188804	16/69 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..346
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810