DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Limch1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_038947830.1	Gene:	Limch1 / 305332	RGDID:	1305269	Length:	1561	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	107/544 - (19%)
Similarity:	173/544 - (31%)	Gaps:	196/544 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVAQQLR-------ELSLPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPKPP---- 56
            |.:.|||       :...|:.:....:..:...||||                    ||.|
  Rat  1131 SSSPQLRNEVPEEQDQKKPENEMSGKVELVLSQKVAK--------------------PKSPEPEA 1175

  Fly    57 -IKYNEMPQVPSSRQV----LCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTT 116
             :.:..:.::|.:.|:    |.|:|...|.|| .|:.:.|....|.:       .||:..:.|:.
  Rat  1176 TLTFPFLDKMPETDQLHLPNLNSQELPGSAPL-RVQNSWRRSQFFSQ-------SADSPSSEKSP 1232

  Fly   117 LDNPA---ILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRK 178
            ...|.   ..:.:.|.....|.|.|::.||..:.:..|      ..|.:...|:         :|
  Rat  1233 ASTPFKFWAWDPEEERRRQEKWQQEQERLLQERYQKEQ------DKLKEEWEKA---------QK 1282

  Fly   179 EIETLE--LLTDETKISAS-----TYSNVNETAMDSSHSSTQ------KM-LSVCTNF------- 222
            |:|..|  ...:|.||...     |.|:.:...:.:|.|.|:      || |..|.:.
  Rat  1283 EVEEEERRYYEEERKIIEDTVVPFTISSSSADQLSTSSSVTEGSGTRNKMDLENCQDRDKERRQN 1347

  Fly   223 --ISDNEKDE--------LP---------PPPSPESAVSSSYS---------ELRHATLEFNKPI 259
              :.:|:.|.        ||         |..:.|::||...|         |..|.........
  Rat  1348 TPLQENDSDSSLKARESGLPEEHSSLTQSPSANSENSVSKGISQDQQPETEAEASHCGTNPQSAQ 1412

  Fly   260 DYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVADTLPRESYNLHNSYVNDN 324
            |...|.|.:||             .|.||        |.:.|:
  Rat  1413 DPPWNQQISNP-------------PTSKS--------EDVKPK---------------------- 1434

  Fly   325 NPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPVQELENYGRCV 389
              .::.|.:|::.||:      .|..|.     .|...|.:.|..:..| ||.|.|....|.|.:
  Rat  1435 --TLALEKSINHQIES------PGERRK-----KSPRENFRAGPLSPCS-PTPPGQSPNRYKRSI 1485

  Fly   390 K----CNSRVLGESSGCT----AMDQIYHIFCFTCTDCQINL----QGKPFYALDGKPYCEYDYL 442
            .    |:|..|....|..    .::..:||.||.|..|:..|    .|......:|...|...|:
  Rat  1486 SGKKLCSSCGLALGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCTDCYM 1550

  Fly   443 QTLEKCSVCMEPILERILRATGKP 466
            ::                |:.|:|
  Rat  1551 RS----------------RSAGQP 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/64 (22%)
		LIM2_LPP	448..507	CDD:188740	3/19 (16%)
		LIM3_LPP	508..575	CDD:188821
Limch1	XP_038947830.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:406382
		PRK07764	<276..>412	CDD:236090
		DUF4757	<737..868	CDD:406382
		GBP_C	<1245..1282	CDD:419202	9/51 (18%)
		LIM	1491..1548	CDD:214528	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900