DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and LIMCH1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_011511944.1	Gene:	LIMCH1 / 22998	HGNCID:	29191	Length:	1655	Species:	Homo sapiens

Alignment Length:	516	Identity:	93/516 - (18%)
Similarity:	156/516 - (30%)	Gaps:	188/516 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KISNNQNASVKRRLD---IPPKPP-----IKYNEMPQVPSSRQVLCSREPLYSQPLIGVEKTMRG 92
            |..|..:..|:..|.   :.||.|     :.:..:.::|.:.|       |:...|...|.....
Human  1240 KPENEMSGKVELVLSQKVVKPKSPEPEATLTFPFLDKMPEANQ-------LHLPNLNSQESPGTA 1297

  Fly    93 HMPFR---KYLSSEF--GVADTQINRKTTLDNPAI----LEQQLEALAYHKLQMEKKGLLGVQAK 148
            .:|.|   .:..|:|  ...|:..:.|:.:..|..    .:.:.|.....|.|.|::.||..:.:
Human  1298 SVPLRVQNSWRRSQFFSQSVDSPSSEKSPVMTPQFKFWAWDPEEERRRQEKWQQEQERLLQERYQ 1362

  Fly   149 PTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLE--LLTDETKI----------SASTYSNVN 201
            ..|      ..|.:...|:         :||:|..|  ...:|.||          |:|:...::
Human  1363 KEQ------DKLKEEWEKA---------QKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLS 1412

  Fly   202 ETAMDSSHSSTQKMLSV--CTN------------------FISDNEKDELPPPPS-PESA----- 240
            .::..:..|.|...:.:  |.:                  .:...|.|.|....| .|.|
Human  1413 TSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSG 1477

  Fly   241 --VSSSYSELRHATLEFNKP---------IDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDS 294
              ||....|......|...|         .|..||.||:||                    |:.|
Human  1478 NPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNP--------------------THSS 1522

  Fly   295 IYEPINPRPCVADTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNS 359
              |.:.|:     |||.:.             :|:|:                         :.|
Human  1523 --EDVKPK-----TLPLDK-------------SINHQ-------------------------IES 1542

  Fly   360 IHRNDKEGLKNYISI-------PTEPVQELENYGRCVK----CNSRVLGESSGCT----AMDQIY 409
            .....|:..:.:...       ||.|.|....|.|.:.    |:|..|....|..    .::..:
Human  1543 PSERRKKSPREHFQAGPFSPCSPTPPGQSPNRYKRSISGKKLCSSCGLPLGKGAAMIIETLNLYF 1607

  Fly   410 HIFCFTCTDCQINL----QGKPFYALDGKPYCEYDYLQTLEKCSVCMEPILERILRATGKP 466
            ||.||.|..|:..|    .|......:|...|...|:::                |:.|:|
Human  1608 HIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRS----------------RSAGQP 1652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/64 (22%)
		LIM2_LPP	448..507	CDD:188740	3/19 (16%)
		LIM3_LPP	508..575	CDD:188821
LIMCH1	XP_011511944.1	CH	26..138	CDD:237981
		DUF4757	250..>311	CDD:292571
		DUF4757	813..961	CDD:292571
		GBP_C	<1340..1377	CDD:303769	9/51 (18%)
		LIM	1585..1642	CDD:214528	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900