DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and FHL1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_006724806.1	Gene:	FHL1 / 2273	HGNCID:	3702	Length:	339	Species:	Homo sapiens

Alignment Length:	206	Identity:	53/206 - (25%)
Similarity:	82/206 - (39%)	Gaps:	23/206 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLE---KCS 449
            ||:|...:..:|......::.:|..||.|..|...|..:.|.|.|.|..|  :...|.|   ||.
Human    56 CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILC--NKCTTREDSPKCK 118

  Fly   450 VCMEPIL--ERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCK 512
            .|.:.|:  ::.:...|..:|..||||..| |.:.|...........||:|....|||..|..|.
Human   119 GCFKAIVAGDQNVEYKGTVWHKDCFTCSNC-KQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCN 182

  Fly   513 QPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCN----AKR 573
            :.|...       .:...|:.:|.:|:.|..|    |.:..|:....::|...|..|.    ||:
Human   183 KAITSG-------GITYQDQPWHADCFVCVTC----SKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236

  Fly   574 VQALTNRMTSE 584
            .....|.:|.:
Human   237 CAGCKNPITGK 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	15/52 (29%)
		LIM2_LPP	448..507	CDD:188740	18/60 (30%)
		LIM3_LPP	508..575	CDD:188821	15/70 (21%)
FHL1	XP_006724806.1	LIM	<21..49	CDD:413332
		LIM1_FHL1	56..109	CDD:188730	15/54 (28%)
		LIM2_FHL1	117..174	CDD:188808	15/57 (26%)
		LIM3_FHL1	178..230	CDD:188813	13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810