DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Zfp185

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_033575.3	Gene:	Zfp185 / 22673	MGIID:	108095	Length:	486	Species:	Mus musculus

Alignment Length:	555	Identity:	105/555 - (18%)
Similarity:	172/555 - (30%)	Gaps:	181/555 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPLVCIGHGKVAKLVAKISNNQNASVKRRL----------------DIPPKPPIKYNEMPQVPSS 68
            |.|..||.|:......:..||....:|.|.                |...:|..::|......|.
Mouse     4 SSLGSIGKGRTVPSGEEERNNILRQMKVRTTLKGDQSWITKHDDSEDHTIEPLSRHNRATSFSSV 68

  Fly    69 RQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNPAILEQQLEAL-AY 132
            |....:|.|....|   ....:||  .|.:.:.|.   :.:|.....|...|.....||.|. :.
Mouse    69 RDESNARSPNARAP---AGYIIRG--VFTRTIDSS---SHSQHRPSKTNGAPRSASGQLGAANSG 125

  Fly   133 HKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTDETKISASTY 197
            |.||.....:.....|...|.|.....:|.|..:.:.::.....|:....|.:|   .|.:...:
Mouse   126 HPLQSSGYKMTTEDYKKLAPYNIRRSSISGTEEEEVPFTPDEQKRRSQAALGVL---RKTAPREH 187

  Fly   198 SNVNETAMDSSHSSTQKMLSVCTNFISDN----EKDELP----PPPS---PESAVSSSYSE-LRH 250
            |.|...|..::.|.||::.|   .|::..    ::|.||    .||:   |:...|||.:| :.|
Mouse   188 SYVLSAAKKTTSSPTQELQS---PFLAKRVDVVDEDVLPEKNQEPPALARPDPGRSSSTTEKIAH 249

  Fly   251 ATL---------------EFNKPIDYLQNNQTTNPL-QIYANQYAMQHDATGKSSSTYD-SIYEP 298
            ..:               ..:.|....:||.....: :|.......|.|.|..|....| ||.||
Mouse   250 RQITPPTAELHLVAPDLEALSTPDSCEENNAAPKIIKEIPGTLQDGQSDPTVASQQLADLSILEP 314

  Fly   299 --------------------INPRPC-----VADTLPRESYNLHNSYVNDNNPNISHEYNISNSI 338
                                ::|..|     ::||..:....:         |.:|.:.:.|::|
Mouse   315 QGSPSGAEQQIKAEDCTNMLMSPSSCMVTVTISDTSEQSQLCV---------PGVSSKVDSSSTI 370

  Fly   339 EANQTLYIHGNARTTFYDVN-----SIHRNDKEGLKNYISI-------------PTEPVQELENY 385
            :.  .|::.....|:  :|:     |.|.:....:::.:.:             |||.|
Mouse   371 KG--ILFVKEYMNTS--EVSSGKPVSSHCDSPSSIEDSLDLAKKAPHEGTPSERPTEGV------ 425

  Fly   386 GRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEKCSV 450
                                          ||.|...:|..|..              |||...:
Mouse   426 ------------------------------CTYCSHEIQDCPKI--------------TLEHLGI 446

  Fly   451 CMEPILERILRATGKPYHPQCFTCVVCGKSLDGLL 485
            |.               |..||.|.:|.|.:..||
Mouse   447 CC---------------HEYCFKCGICNKPMGDLL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	5/52 (10%)
		LIM2_LPP	448..507	CDD:188740	9/38 (24%)
		LIM3_LPP	508..575	CDD:188821
Zfp185	NP_033575.3	LIM	425..481	CDD:214528	18/107 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900