DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Pdlim2

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001240665.1	Gene:	Pdlim2 / 213019	MGIID:	2384850	Length:	349	Species:	Mus musculus

Alignment Length:	384	Identity:	75/384 - (19%)
Similarity:	125/384 - (32%)	Gaps:	98/384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 YSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNPAILEQQLEALAYHKLQMEKKGLL 143
            :..|:|..:.|.||..........:..||   ||.::.       |..|.|.|..|::..
Mouse    23 FHTPIIVTKVTERGKAEAADLRPGDIIVA---INGQSA-------ENMLHAEAQSKIRQS----- 72

  Fly   144 GVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTDETKISASTYSNVNETAMDSS 208
                         ..||...|.:|...|. |....| .:||:|....:.|..|:.:...:...:.
Mouse    73 -------------ASPLRLQLDRSQTASP-GQTNGE-GSLEVLATRFQGSLRTHRDSQSSQRSAC 122

  Fly   209 HSSTQKMLSVCTNFISDNEKDELPPPPSP-----ESAVSSSYSELRHATLEFNKPIDYLQNNQTT 268
            .|........|:.|       ..|||.||     |..:..|:..|.|
Mouse   123 FSPVSLSPRPCSPF-------STPPPTSPVALSKEDMIGCSFQSLTH------------------ 162

  Fly   269 NPLQIYANQYAMQHDATGKS---SSTYDS-----IYEPINPRPCVADTLPRESYNLHNSYVNDNN 325
            :|....|:........|.:.   ||..||     ::.|..|......:|..|..:.....:.:|.
Mouse   163 SPGLAAAHHLTYPGHPTSQQAGHSSPSDSAVRVLLHSPGRPSSPRFSSLDLEEDSEVFKMLQENR 227

  Fly   326 -----PNISHEYN-ISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPT-EPVQELE 383
                 |..|..:. :..::||.:      ...|..:..:|        |.:..|:|| ..:....
Mouse   228 QGRAAPRQSSSFRLLQEALEAEE------RGGTPAFVPSS--------LSSQASLPTSRALATPP 278

  Fly   384 NYGRCVKCNSRVLGES----SGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCE 438
            ....|.||:..:..::    .|     :..|..|:||.||.:||:.:..:.:..:.|||
Mouse   279 KLHTCEKCSVNISNQAVRIQEG-----RYRHPGCYTCADCGLNLKMRGHFWVGNELYCE 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	15/55 (27%)
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
Pdlim2	NP_001240665.1	PDZ_signaling	9..80	CDD:238492	16/84 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..147		20/81 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..212		8/42 (19%)
		DUF4749	<198..252	CDD:406377	9/59 (15%)
		LIM_Mystique	283..335	CDD:188833	15/55 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910