DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and prkl-1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_741435.2	Gene:	prkl-1 / 177463	WormBaseID:	WBGene00022727	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	209	Identity:	53/209 - (25%)
Similarity:	87/209 - (41%)	Gaps:	20/209 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 RCVKCNSRV-LGESSGCTA-MDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLE-KC 448
            :|.||..|: .||.|...| ..:.||..||.|..|.:.|....::|.|.:.||...:.:.:: :|
Worm   148 KCEKCPKRLEEGEISVMAARTGKRYHPSCFRCQTCDVLLVDLIYFAHDNQIYCGRHHAEQVKPRC 212

  Fly   449 SVCMEPIL-ERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAP-RCCVC 511
            :.|.|.|. :..|.|.|:.:|...|.|..|...|....: :...|:..|:..||...:. .|..|
Worm   213 AKCDEVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKY-MQRANKPVCLKCFHSSSSTFSCTTC 276

  Fly   512 KQPIMPDPGQEETIRVVALDRSFH--LECYKCEDCGLLLSSEAEGRGCYPLDDHVLC--KSCNAK 572
            :.....|     |..:...|..:|  .||:.|..|...|......|    :.:.:.|  ::|..:
Worm   277 RLSFSSD-----TPHMSQGDLHWHASAECFCCCVCSKNLLGVKYSR----VGESLFCGYQTCGGE 332

  Fly   573 RVQAL-TNRMTSEH 585
            ..:.| .:|:.|.|
Worm   333 DEELLDEDRLGSPH 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	19/54 (35%)
		LIM2_LPP	448..507	CDD:188740	16/60 (27%)
		LIM3_LPP	508..575	CDD:188821	14/70 (20%)
prkl-1	NP_741435.2	PET_Prickle	48..144	CDD:193602
		LIM1_Testin_like	149..204	CDD:188726	19/54 (35%)
		LIM2_Testin_like	210..262	CDD:188727	14/52 (27%)
		LIM	283..324	CDD:295319	10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910