DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and DLX5

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_005212.1	Gene:	DLX5 / 1749	HGNCID:	2918	Length:	289	Species:	Homo sapiens

Alignment Length:	198	Identity:	40/198 - (20%)
Similarity:	65/198 - (32%)	Gaps:	73/198 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 VQAKPTQPLNSFTKP--------LSKTLSKSLIYSN--LGSVRKEIETLELLT--DETKISAS-- 195
            |.:...||....|:|        ..|......|||:  |.::::..:..:.|.  :..:::||
Human   111 VPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLG 175

  Fly   196 -TYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPPSPESA------------------V 241
             |.:.| :....:..|..:|::          :..|:||..||.|:                  .
Human   176 LTQTQV-KIWFQNKRSKIKKIM----------KNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGS 229

  Fly   242 SSSYSELRHA---TLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPIN--- 300
            |.|.|...||   |...:....||:|                       |:|.|.|....||
Human   230 SRSLSHHPHAHPPTSNQSPASSYLEN-----------------------SASWYTSAASSINSHL 271

  Fly   301 PRP 303
            |.|
Human   272 PPP 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
DLX5	NP_005212.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		DLL_N	32..118	CDD:315147	1/6 (17%)
		Homeobox	140..193	CDD:306543	10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..251		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..289		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910