DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Ajuba

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_034720.2	Gene:	Ajuba / 16475	MGIID:	1341886	Length:	547	Species:	Mus musculus

Alignment Length:	205	Identity:	103/205 - (50%)
Similarity:	138/205 - (67%)	Gaps:	6/205 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 EPVQELENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDY 441
            ||....:.:|.|:|||..:.|:|:.|.|:|.:||..||.|..|...|:.|.||:::|..|||.||
Mouse   336 EPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDY 400

  Fly   442 L-----QTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFH 501
            |     :..|||.||...|||:||:|.||.|||.||.|:||.|.|||:.||||.:||.||:||:|
Mouse   401 LFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYH 465

  Fly   502 KKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLC 566
            |.:||:|..|.|||:|..|.|:.:||:::||.:|.|||.||||.:.||.| ||..|:|||.|:||
Mouse   466 KNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDE-EGCCCFPLDGHLLC 529

  Fly   567 KSCNAKRVQA 576
            ..|:.:|:.|
Mouse   530 HGCHMQRLSA 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	23/52 (44%)
		LIM2_LPP	448..507	CDD:188740	36/58 (62%)
		LIM3_LPP	508..575	CDD:188821	34/66 (52%)
Ajuba	NP_034720.2	PreLIM	1..344		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182
		Nuclear localization signal. /evidence=ECO:0000255	289..297
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..332
		LIM1_Ajuba_like	347..400	CDD:188738	23/52 (44%)
		LIM2_Ajuba_like	412..464	CDD:188741	32/51 (63%)
		LIM3_Ajuba_like	472..533	CDD:188822	32/61 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810