DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and PRICKLE1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001138353.1	Gene:	PRICKLE1 / 144165	HGNCID:	17019	Length:	831	Species:	Homo sapiens

Alignment Length:	337	Identity:	78/337 - (23%)
Similarity:	121/337 - (35%)	Gaps:	67/337 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 PLQIYANQYAMQHDATGKSSSTYDS-------IYEPINPRP--------CVADTLPRESYNLHNS 319
            ||::......:.......|:|..||       .:.|...||        |    ||.|..    .
Human     2 PLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFAC----LPEEKV----P 58

  Fly   320 YVNDNNPNISHE-----YNI---SNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGL-KNYISIP 375
            ||  |:|...|.     |.:   .|.:...|:|   .........|.|..|. ||.| :..|.:.
Human    59 YV--NSPGEKHRIKQLLYQLPPHDNEVRYCQSL---SEEEKKELQVFSAQRK-KEALGRGTIKLL 117

  Fly   376 TEPVQELENYGRCVKCNSRVLGESSGCTAM----DQIYHIFCFTCTDCQINLQGKPFYALDGKPY 436
            :..|.    :..|.:|..::.|......|.    ...:|..||.|..|...|....::..|||.:
Human   118 SRAVM----HAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIH 178

  Fly   437 CEYDYLQTLE-KCSVCMEPIL-ERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITD 499
            |...:.:.|: :||.|.|.|. :....|.|:.:|.:.|.|:.|...|.|..: :....:.:|...
Human   179 CGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRY-IMKDGRPFCCGC 242

  Fly   500 FHKKFAPRCCVCKQPIMPDPGQEETIRVVALD-RSFHL--ECYKCEDCGLLLSSEAEGRGC--YP 559
            |...:|..|..|.:.|..|..|      :..| :.:|.  .|:.|..|      :|...||  .|
Human   243 FESLYAEYCETCGEHIGVDHAQ------MTYDGQHWHATEACFSCAQC------KASLLGCPFLP 295

  Fly   560 LDDHVLC-KSCN 570
            ....:.| |:|:
Human   296 KQGQIYCSKTCS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	14/56 (25%)
		LIM2_LPP	448..507	CDD:188740	16/59 (27%)
		LIM3_LPP	508..575	CDD:188821	17/69 (25%)
PRICKLE1	NP_001138353.1	PET_Prickle	22..118	CDD:193602	26/109 (24%)
		LIM1_Prickle_1	126..184	CDD:188867	14/57 (25%)
		LIM2_Prickle	189..244	CDD:188802	14/55 (25%)
		LIM3_Prickle	249..307	CDD:188804	16/69 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810