DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and AgaP_AGAP009503

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_310193.4	Gene:	AgaP_AGAP009503 / 1271408	VectorBaseID:	AGAP009503	Length:	499	Species:	Anopheles gambiae

Alignment Length:	556	Identity:	259/556 - (46%)
Similarity:	325/556 - (58%)	Gaps:	93/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QVPSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKY--LSSEFGVADTQ-----INRKTTLDNPA 121
            |||.|..|....||.:|..|.|....:..|    .|  :|:..|.|...     ..||.|||:..
Mosquito     1 QVPKSSNVKQYCEPSFSTVLEGQASNLDEH----AYTNVSNNGGNATRSGGGKLAARKVTLDDAL 61

  Fly   122 ILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLELL 186
            .|:...|||.:||..::......:|.:.....|          ::.|||||            ::
Mosquito    62 ELQHVKEALEHHKRTLDANRSKSLQGQGAHVKN----------NEGLIYSN------------IM 104

  Fly   187 TDETKISASTY--SNVNETAMDSSHSSTQKM-LSVCTNFISDNEKDELPPPPSPESAVSSSYSEL 248
            .:.|...|..:  ..::|..........|.: |::....:.||: ||.||||||   ||||||||
Mosquito   105 HNPTNPGAKPFPQRQISEELPPPPPQDMQPLQLTLNALTLEDND-DEFPPPPSP---VSSSYSEL 165

  Fly   249 RHATLEFNKPIDYLQNNQTTNPLQ---------IYANQYAMQHDA-------TGKSSSTYDSIYE 297
            |.||       |.....:.:.|..         :|||.  |.|.:       :.:.|:||:||||
Mosquito   166 RRAT-------DLPHMGRQSQPTYTMVGPGAGGLYANN--MHHQSLYGTYGMSSQGSTTYESIYE 221

  Fly   298 PINPRPCVADTLPRESYNLHNSYVND---NNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNS 359
            |||||| .:....|.:|:|:..|||.   |:||.|...:.|...:..|
Mosquito   222 PINPRP-PSQMSGRSNYSLYAPYVNSHGINSPNDSIITSASQQQQQQQ----------------- 268

  Fly   360 IHRNDKEGLKNYISIPT------EPVQELENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTD 418
             ||:::..:.....:.|      :.:.:.|::|.||||..||:||.:||||||:||||.||||..
Mosquito   269 -HRHNQGSMSKGAEVDTLTDLLVQSIHDQESFGTCVKCGERVVGEKTGCTAMDKIYHIACFTCHQ 332

  Fly   419 CQINLQGKPFYALDGKPYCEYDYLQTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDG 483
            |||||||||||.|||||||:.|||.||||||||::|||||||||||||||||||||:||||||||
Mosquito   333 CQINLQGKPFYGLDGKPYCKEDYLNTLEKCSVCLKPILERILRATGKPYHPQCFTCIVCGKSLDG 397

  Fly   484 LLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLL 548
            :.||||||||.:||.||||||||||||||.||||.||::||:||||||||||:.|||||||||:|
Mosquito   398 IPFTVDATNQIHCIDDFHKKFAPRCCVCKMPIMPGPGEDETVRVVALDRSFHINCYKCEDCGLVL 462

  Fly   549 SSEAEGRGCYPLDDHVLCKSCNAKRVQALTNRMTSE 584
            |||||||||||||||:|||||||||||.||:.||:|
Mosquito   463 SSEAEGRGCYPLDDHILCKSCNAKRVQTLTSHMTTE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	40/52 (77%)
		LIM2_LPP	448..507	CDD:188740	50/58 (86%)
		LIM3_LPP	508..575	CDD:188821	57/66 (86%)
AgaP_AGAP009503	XP_310193.4	LIM1_LPP	302..355	CDD:188737	40/52 (77%)
		LIM2_LPP	362..421	CDD:188740	50/58 (86%)
		LIM3_LPP	422..489	CDD:188821	57/66 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	136	1.000	Domainoid score	I10082
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19894
Inparanoid	1	1.050	445	1.000	Inparanoid score	I3508
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283353at33208
OrthoFinder	1	1.000	-	-		FOG0001663
OrthoInspector	1	1.000	-	-		oto106059
Panther	1	1.100	-	-	LDO	PTHR24207
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2600
TreeFam	1	0.960	-	-
	12	11.930