DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and LDB3

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	723	Identity:	153/723 - (21%)
Similarity:	242/723 - (33%)	Gaps:	233/723 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVAQQLRELSLPKGDTG----SPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPKPPIKYNEMP 63
            |:..|..:..:|...|.    :||..|.|.|...|      :.|.|:     :.|.|..:....|
Human    77 SLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPAL------DTNGSL-----VAPSPSPEARASP 130

  Fly    64 QVPSSRQVLCSREPLYSQP------------------------------LIGVEKTMRGHMPFRK 98
            ..|.:.::..:..|.:|:|                              |:| .|.:.|....|:
Human   131 GTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLG-PKALPGSSQPRQ 194

  Fly    99 YLSSEFGVADTQINRKTT-------------------LD-----NPAILEQQLEALAYHKLQMEK 139
            | ::..|:...:..|:..                   .|     ||:.|:.  .||:.|| .:|.
Human   195 Y-NNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGADYQERFNPSALKD--SALSTHK-PIEV 255

  Fly   140 KGLLG----VQAKPTQPLNSFTK----------------------PLSKTL---SKSLIY----- 170
            |||.|    :.|:...|::.:::                      |: |.|   |.|.:|
Human   256 KGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLPI-KDLAVDSASPVYQAVIK 319

  Fly   171 ----------------SNLGS----VRKEIETLELLTD-------ETKISASTYS-NVNETAMDS 207
                            |||.|    :..::...|.:.|       .::..||:|| .|..::..:
Human   320 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRPQASSYSPAVAASSAPA 384

  Fly   208 SHSSTQKMLSVCTNFISDNEKDELPPPPSPESAV-------SSSYSELRHATLEFNKPIDYLQNN 265
            :|:|                ..|.|..|:|:..|       .|.|..:..:|...:...:|....
Human   385 THTS----------------YSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTP 433

  Fly   266 QTTNPLQIYANQYAMQHDATGKSSSTYD----SIYEP-----INPRPCV------ADTLPRESYN 315
            .|.:|...|....|..:  |.....||.    ..|.|     .||.|.|      |:...|..:.
Human   434 YTPSPAPAYTPSPAPAY--TPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWV 496

  Fly   316 LHNSYVNDNNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEP-- 378
            ..:|:.....|..|     :.|| :.|||...|.|.|                      |..|
Human   497 TDDSFSQKFAPGKS-----TTSI-SKQTLPRGGPAYT----------------------PAGPQV 533

  Fly   379 -------VQELENYGR------CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYA 430
                   ||..|.:..      |..||:.:.|..  ..||.:.:|...|||..|:.:|....|..
Human   534 PPLARGTVQRAERFPASSRTPLCGHCNNVIRGPF--LVAMGRSWHPEEFTCAYCKTSLADVCFVE 596

  Fly   431 LDGKPYCEYDYLQTLEK-CSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQN 494
            .....|||..|.|.... |:.|...|:..::.|..:.:|..||.|..|.|.....||.:: ..:.
Human   597 EQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHME-DGEP 660

  Fly   495 YCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYP 559
            ||..|:...|:.:|..|..|:  :.|.:   .:.||..::|..|:.|..|.:.|    ||:..|.
Human   661 YCEKDYINLFSTKCHGCDFPV--EAGDK---FIEALGHTWHDTCFICAVCHVNL----EGQPFYS 716

  Fly   560 LDDHVLCK 567
            ..|..|||
Human   717 KKDRPLCK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	16/52 (31%)
		LIM2_LPP	448..507	CDD:188740	16/58 (28%)
		LIM3_LPP	508..575	CDD:188821	18/60 (30%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492	1/3 (33%)
		DUF4045	<77..180	CDD:330572	19/113 (17%)
		ZM	189..214	CDD:128974	4/25 (16%)
		DUF4749	263..353	CDD:318205	12/90 (13%)
		Atrophin-1	<387..554	CDD:331285	41/212 (19%)
		LIM1_ZASP_Cypher	556..607	CDD:188838	16/52 (31%)
		LIM2_Enigma_like	615..666	CDD:188748	14/51 (27%)
		LIM3_Enigma_like	674..727	CDD:188749	18/60 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910