DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and pxn

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_031752049.1	Gene:	pxn / 100216044	XenbaseID:	XB-GENE-941407	Length:	1070	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	146/676 - (21%)
Similarity:	237/676 - (35%)	Gaps:	200/676 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KISNNQNASVKRRLDIP-----PK---------PPIKYNEMPQVPSSRQVLCSREPLYSQPLIGV 86
            |.|..:||.|......|     |:         .|::: :....|.:.|....:|   ||.:|..
Frog   436 KTSQFENAVVSSDESCPVCVESPRGSAISGEFGSPLEF-DFQSDPKAIQAFWEKE---SQIIISP 496

  Fly    87 EKTMRGHMPFRKYLSSEFGVADTQINRKTTLDN---------------PAILEQQLEALAYHKLQ 136
            |.:.|..:...:.:.|       .|.|...:.|               |||..:.   .:..:|.
Frog   497 EASTRERISASRQMKS-------LIERTKEIPNVHPMYRDLSPRRKFGPAIYNKN---PSQDRLI 551

  Fly   137 MEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYS-----NLGSVRKEIETL-------ELLTDE 189
            .|..|..|:..:.|     ...|....|::.:|.:     |:....::||.:       :|:...
Frog   552 EELHGRFGIDKQET-----CKTPEDDWLTEGVIITSRPSKNMLPSEQQIEKIIIPPDSPQLMRKS 611

  Fly   190 TKISASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPP-------------SPE--- 238
            ..:|:|....|:.|.: .|.|::....|.|           :||||             ||:
Frog   612 FSVSSSPPGTVHRTRL-VSKSTSPAQPSAC-----------VPPPPPLPPIQSPAFIPHSPQQFP 664

  Fly   239 --SAVSSSYSEL-RHATLEFNKPID---YLQNN--QTTNPLQIYANQYAMQHDATGKSSSTYDSI 295
              .|....|.:| |...|..||.:.   :|..:  :|..|.:.:.: ...|.|.|        .:
Frog   665 SWKAAGDDYQDLSRPLPLPHNKELSATRFLPPSPLKTLPPNKSFVS-VGCQTDET--------PL 720

  Fly   296 YEPIN------------PRPCVADTLPRESYNL--------HNSYVNDNNPNISHEYNISNSIEA 340
            :.||.            .||..:.|||.:|..|        |        |...|..:.|:...:
Frog   721 FPPIQLISPQTCSPALFARPPPSPTLPDKSSGLVLVPSLWPH--------PEERHLTSNSDMFPS 777

  Fly   341 NQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPVQELENY------------------GR 387
            :.......|      |:.||....|....:..|...:|..:|:|.                  |.
Frog   778 SSKCLAPSN------DIPSIMAKGKSVSNSPPSNTPKPGSQLDNMLGSLQSDLNKLGVATVAKGV 836

  Fly   388 CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLE-KCSVC 451
            |..|...:.|:.  .|||.:.:|...|.||.||..:..:.|:..||:||||.||..... :|..|
Frog   837 CGACKKPIAGQV--VTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCFYC 899

  Fly   452 MEPILERILRATGKPYHPQCFTCVVCG--------KSLDGLLFTVDATNQNYCITDFHKKFAPRC 508
            ..|||::::.|..:.:||:.|.|..||        ...||         :.||..|:...|||:|
Frog   900 NGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHERDG---------KAYCRKDYFDMFAPKC 955

  Fly   509 CVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDC------GLLLSSEAEGRGCYPLDDH---- 563
            ..|...|:.:       .:.||:..:|.||:.|.:|      |...  |.:|:....:..|
Frog   956 GGCTHAILEN-------YISALNTLWHPECFVCRECFTPFINGSFF--EHDGQPYCEMHYHERRG 1011

  Fly   564 VLCKSC----NAKRVQALTNRMTSEH 585
            .||..|    ..:.:.|:..:...||
Frog  1012 SLCSGCQKPITGRCITAMGKKFHPEH 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	19/52 (37%)
		LIM2_LPP	448..507	CDD:188740	19/66 (29%)
		LIM3_LPP	508..575	CDD:188821	17/80 (21%)
pxn	XP_031752049.1	Paxillin	45..234	CDD:397550
		LIM1_Paxillin_like	837..889	CDD:259830	20/53 (38%)
		LIM2_Paxillin	896..947	CDD:188791	16/59 (27%)
		LIM3_Paxillin_like	955..1007	CDD:188724	13/60 (22%)
		LIM4_Paxillin	1014..1065	CDD:188795	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910