DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32006 and Foxo1

DIOPT Version :10

Sequence 1:NP_726538.1 Gene:CG32006 / 317817 FlyBaseID:FBgn0052006 Length:443 Species:Drosophila melanogaster
Sequence 2:NP_001178775.1 Gene:Foxo1 / 84482 RGDID:620283 Length:649 Species:Rattus norvegicus


Alignment Length:285 Identity:67/285 - (23%)
Similarity:106/285 - (37%) Gaps:60/285 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 NYSHIIGMAMLQNG--RITLQQLCSWIEAKFAFFRVR------KKWNNSIRHNLSLHHCFRNRKR 206
            :|:.:|..|:..:.  |:||.|:..|:.....:|:.:      ..|.||||||||||..|...:.
  Rat   158 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 222

  Fly   207 EERGKGGYWELGVDPKKCDRKRIRNRKIFHPTQNQTAKLQYEHLTEIQQAKSARKNHSRHIKKSK 271
            |..||..:|.|                  :|...::.|........:.......|:..|..||. 
  Rat   223 EGTGKSSWWML------------------NPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKK- 268

  Fly   272 TSSL------PETSEANIFNVVPHK--KHNIADENDGQRQLQTINKDDILKKKSELDTIVSSTES 328
             :||      |..|..:.|:..|..  .|:    ||......|...    :..|...||......
  Rat   269 -ASLQSGQEGPGDSPGSQFSKWPASPGSHS----NDDFDNWSTFRP----RTSSNASTISGRLSP 324

  Fly   329 FLTESQNLNCFNSHKTDTTNTPISAEKNFCTFNNFYSEMTPVLASNSNIVEDQNVSTDVSWPSHP 393
            .:||..:|...:.|   :...|.||.|...|.        |.|:..||....:|:..:::..|.|
  Rat   325 IMTEQDDLGDGDVH---SLVYPPSAAKMASTL--------PSLSEISNPENMENLLDNLNLLSSP 378

  Fly   394 CNITINYDYTNFQPIVDSIAEQFQC 418
            .::|::   |...|  .|:.:|..|
  Rat   379 TSLTVS---TQSSP--GSMMQQTPC 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32006NP_726538.1 Forkhead 146..217 CDD:459732 25/74 (34%)
Foxo1NP_001178775.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..151
FH_FOXO1 145..243 CDD:410834 27/102 (26%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 205..212 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..339 25/141 (18%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 228..231 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250 245..247 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 277..557 33/146 (23%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 357..453 11/47 (23%)
FOXO_KIX_bdg 417..498 CDD:465228
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 456..460
FOXO-TAD 591..627 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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