Protein Alignment CG32006 and Foxo1

DIOPT Version :10

• Sequence 1: NP_726538.1
• Gene: CG32006 / 317817
• FlyBaseID: FBgn0052006
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Alignment Length: 285
• Identity: 67/285 - (23%)
• Similarity: 106/285 - (37%)
• Gaps: 60/285 - (21%)

  Fly   150 NYSHIIGMAMLQNG--RITLQQLCSWIEAKFAFFRVR------KKWNNSIRHNLSLHHCFRNRKR 206
            :|:.:|..|:..:.  |:||.|:..|:.....:|:.:      ..|.||||||||||..|...:.
Mouse   161 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 225

  Fly   207 EERGKGGYWELGVDPKKCDRKRIRNRKIFHPTQNQTAKLQYEHLTEIQQAKSARKNHSRHIKKSK 271
            |..||..:|.|                  :|...::.|........:.......|:..|..||.
Mouse   226 EGTGKSSWWML------------------NPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKK- 271

  Fly   272 TSSL------PETSEANIFNVVPHK--KHNIADENDGQRQLQTINKDDILKKKSELDTIVSSTES 328
             :||      |..|..:.|:..|..  .|:    ||......|...    :..|...||......
Mouse   272 -ASLQSGQEGPGDSPGSQFSKWPASPGSHS----NDDFDNWSTFRP----RTSSNASTISGRLSP 327

  Fly   329 FLTESQNLNCFNSHKTDTTNTPISAEKNFCTFNNFYSEMTPVLASNSNIVEDQNVSTDVSWPSHP 393
            .:||..:|...:.|   :...|.||.|...|.        |.|:..||....:|:..:::..|.|
Mouse   328 IMTEQDDLGDGDVH---SLVYPPSAAKMASTL--------PSLSEISNPENMENLLDNLNLLSSP 381

  Fly   394 CNITINYDYTNFQPIVDSIAEQFQC 418
            .::|::   |...|  .|:.:|..|
Mouse   382 TSLTVS---TQSSP--GSMMQQTPC 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32006	NP_726538.1	Forkhead	146..217	CDD:459732	25/74 (34%)
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154
		FH_FOXO1	148..246	CDD:410834	27/102 (26%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		25/141 (18%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		33/146 (23%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		11/47 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		6/24 (25%)
		FOXO_KIX_bdg	420..501	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506