Protein Alignment CG32006 and FOXO1

DIOPT Version :10

• Sequence 1: NP_726538.1
• Gene: CG32006 / 317817
• FlyBaseID: FBgn0052006
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 65/277 - (23%)
• Similarity: 110/277 - (39%)
• Gaps: 44/277 - (15%)

  Fly   150 NYSHIIGMAMLQNG--RITLQQLCSWIEAKFAFFRVR------KKWNNSIRHNLSLHHCFRNRKR 206
            :|:.:|..|:..:.  |:||.|:..|:.....:|:.:      ..|.||||||||||..|...:.
Human   164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 228

  Fly   207 EERGKGGYWELGVDPKKCDRKRIRNRKIFHPTQNQTAKLQYEHLTEIQQAKSARKNHSRHIKKSK 271
            |..||..:|.|..:..| ..|..|.|.......::.||         .::::|:|..|....:..
Human   229 EGTGKSSWWMLNPEGGK-SGKSPRRRAASMDNNSKFAK---------SRSRAAKKKASLQSGQEG 283

  Fly   272 TSSLPETSEANIFNVVPHKKHNIADENDGQRQLQTINKDDILKKKSELDTIVSSTESFLTESQNL 336
            ....| .|:.:.:...|....|  |:.|.....:.       :..|...||.......:||..:|
Human   284 AGDSP-GSQFSKWPASPGSHSN--DDFDNWSTFRP-------RTSSNASTISGRLSPIMTEQDDL 338

  Fly   337 NCFNSHKTDTTNTPISAEKNFCTFNNFYSEMTPVLASNSNIVEDQNVSTDVSWPSHPCNITINYD 401
            ...:.|   :...|.||.|...|.        |.|:..||....:|:..:::..|.|.::|::
Human   339 GEGDVH---SMVYPPSAAKMASTL--------PSLSEISNPENMENLLDNLNLLSSPTSLTVS-- 390

  Fly   402 YTNFQPIVDSIAEQFQC 418
             |...|  .::.:|..|
Human   391 -TQSSP--GTMMQQTPC 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32006	NP_726538.1	Forkhead	146..217	CDD:459732	25/74 (34%)
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158
		FH_FOXO1	151..249	CDD:410834	27/85 (32%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		23/129 (18%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		30/148 (20%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		10/47 (21%)
		FOXO_KIX_bdg	423..504	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506