DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32006 and FOXC2

DIOPT Version :9

Sequence 1:	NP_726538.1	Gene:	CG32006 / 317817	FlyBaseID:	FBgn0052006	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_005242.1	Gene:	FOXC2 / 2303	HGNCID:	3801	Length:	501	Species:	Homo sapiens

Alignment Length:	224	Identity:	63/224 - (28%)
Similarity:	94/224 - (41%)	Gaps:	28/224 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 KPPFNYSHIIGMAMLQNG---RITLQQLCSWIEAKFAFFRVRKK-WNNSIRHNLSLHHCFRNRKR 206
            |||::|..:|.|| :||.   :|||..:..:|..:|.|:|..|: |.|||||||||:.||....|
Human    72 KPPYSYIALITMA-IQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPR 135

  Fly   207 EER--GKGGYWELGVDPKKCDR----KRIRNRKIFHPTQNQTAKLQYEHLTEIQQAKSARKNHSR 265
            :::  |||.||.|  ||...:.    ..:|.|:.|........|.:..||.|...|.|.....:.
Human   136 DDKKPGKGSYWTL--DPDSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEPPPAASKGAPATP 198

  Fly   266 HIKKSKTSSLPETSEANIFNVVPHKKHNIADENDGQRQLQTINKDDILKKKSELDTIVSSTESFL 330
            |:     :..|:.:|..:          :.........|..|.|.:.|..:|.|.....|..|..
Human   199 HL-----ADAPKEAEKKV----------VIKSEAASPALPVITKVETLSPESALQGSPRSAASTP 248

  Fly   331 TESQNLNCFNSHKTDTTNTPISAEKNFCT 359
            ..|.:.:....|.......|..:.:|..|
Human   249 AGSPDGSLPEHHAAAPNGLPGFSVENIMT 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32006	NP_726538.1	FH	146..217	CDD:294049	35/76 (46%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	38/90 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..208		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..268		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910