DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32006 and Foxg1

DIOPT Version :9

Sequence 1:	NP_726538.1	Gene:	CG32006 / 317817	FlyBaseID:	FBgn0052006	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001153584.1	Gene:	Foxg1 / 15228	MGIID:	1347464	Length:	481	Species:	Mus musculus

Alignment Length:	183	Identity:	60/183 - (32%)
Similarity:	87/183 - (47%)	Gaps:	36/183 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 EYEKLASKYETDVTEKPPFNYSHIIGMAMLQN--GRITLQQLCSWIEAKFAFFRVRKK-WNNSIR 192
            |.:|...||     |||||:|:.:|.||:.|:  .|:||..:..:|...|.::|..|: |.||||
Mouse   163 EGDKKNGKY-----EKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIR 222

  Fly   193 HNLSLHHCFRN--RKREERGKGGYWELGVDPKKCD------RKRIRNRKIFHPTQNQTAKLQYEH 249
            |||||:.||..  |..::.|||.||.|  ||...|      ..::|.|     :....|||.::.
Mouse   223 HNLSLNKCFVKVPRHYDDPGKGNYWML--DPSSDDVFIGGTTGKLRRR-----STTSRAKLAFKR 280

  Fly   250 --------LTEIQQAKSARKNHS-----RHIKKSKTSSLPETSEANIFNVVPH 289
                    ||.:.:|.|.....|     .|.:.|.|.|...|:.|...:.:|:
Mouse   281 GARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPY 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32006	NP_726538.1	FH	146..217	CDD:294049	34/75 (45%)
Foxg1	NP_001153584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..173		4/14 (29%)
		FH	173..261	CDD:214627	38/89 (43%)
		Required for interaction with TLE6. /evidence=ECO:0000269\|PubMed:16314515	241..336		26/100 (26%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810