Protein Alignment anne and ATP2C2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 1240
• Identity: 227/1240 - (18%)
• Similarity: 389/1240 - (31%)
• Gaps: 466/1240 - (37%)

  Fly   322 GLPVHEQISRRIVFGDNEITVP---------LRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYY 377
            ||.......||:..|.||....         |..||..|.|.:|..    .|.||:.....|...
Human    76 GLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGS----ALVSVLTKEYEDAVS 136

  Fly   378 YACVILLMSVFGITVSVLQ---TKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEI 439
            .|..:|::    :||:.:|   ::|:.:.|.|.|....|..   .:|..:.|..|.:||||::.:
Human   137 IATAVLVV----VTVAFIQEYRSEKSLEELTKLVPPECNCL---REGKLQHLLARELVPGDVVSL 194

  Fly   440 PSSGCTLHCDAILIS-GNCILDESMLTGESVPVTKT--PLPSKRDMIFDKTEHARHTLFCGTKVI 501
             |.|..:..|..|.. .:.::|||..|||:.|.:||  ||....|:     ....:.:|.||.|.
Human   195 -SIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDL-----TTLSNIVFMGTLVQ 253

  Fly   502 QTRYIGSKKVLAFVINTGNITAKGELIRSI----LYPPPVDYKFEQDSYKFIQF----LAIIACV 558
            ..|..|      .||.||..:..||:.:.:    ....|:....::...:...|    :.:|..:
Human   254 YGRGQG------VVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLI 312

  Fly   559 GFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINV 623
            |:        .:|...:.:....:.|....:|..||..:.|.......|:....:..   :.:.:
Human   313 GW--------SQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIV---KKLPI 366

  Fly   624 AGSINCC---CFDKTGTL-----------TEDGL--DMWGVVPKSSTNQFQIPLKSVDRLPFDHF 672
            ..::.||   |.||||||           |.|||  ::.||..........:|.|.|.: .|.:.
Human   367 VETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIK-EFSNV 430

  Fly   673 LFGMV-----TCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGG 732
            ..|.:     ..::..|....:||.|.:                                   |.
Human   431 SVGKLVEAGCVANNAVIRKNAVMGQPTE-----------------------------------GA 460

  Fly   733 LSGMAETE--SGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRC--- 792
            |..:|...  |..||...|:                        :|.||:|..:.|:|  :|
Human   461 LMALAMKMDLSDIKNSYIRK------------------------KEIPFSSEQKWMAV--KCSLK 499

  Fly   793 LSDQVFNVYCKGSPEMLKKLCK-------PQSL-PDNYS---QQLSEFAKKGYRIIAIAFKALSH 846
            ..||....:.||:.|.:.:.|.       |..| |...|   |:.......|.|::|:|
Human   500 TEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALA------ 558

  Fly   847 KMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVAR 911
                      |..|: ..:.|||.|.:.:..:....:.:..|:.:.:...|||||.:.||:::.|
Human   559 ----------SGPEL-GRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGR 612

  Fly   912 DCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCF 976
            :.|:.                :..:|..:|.|.:
Human   613 NIGLC----------------NGKLQAMSGEEVD------------------------------- 630

  Fly   977 NSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELG 1041
                 ..|..|...:|||.
Human   631 -----SVEKGELADRVGKV---------------------------------------------- 644

  Fly  1042 IKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYC 1106
                                                     |::.|.||..|..::..||.....
Human   645 -----------------------------------------SVFFRTSPKHKLKIIKALQESGAI 668

  Fly  1107 VAMCGDGANDCGALKVAHAGISLSETEASIASPFTSR---NPTISAVLKVIKEGRAAL--VTSFG 1166
            |||.|||.||..|||.|..||::.:|...::....:.   :...||::..::||:...  :.:|.
Human   669 VAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFV 733

  Fly  1167 IFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSL 1231
            .|:...:.|.:..|::..::::.|.|...|.|::::                   :::..|....
Human   734 RFQLSTSISALSLITLSTVFNLPSPLNAMQILWINI-------------------IMDGPPAQRS 779

  Fly  1232 ISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWF----KAFEPADEDHLGCFENYTMFCISSFQYI 1292
            ...|.:....:.|.|....:.|         |.    ...||.|:|
Human   780 SQKTEVCCTAVRLGVEGRGEST---------WAGRAGLGVEPVDKD------------------- 816

  Fly  1293 ILAFVFSKGAPYRKPLWS------NWPLCLAFIVNLCIIVYLVLY------PSDWVASFFQLIVP 1345
                      .:|:|..|      :..|.|..:::..||:...|:      |.|..::      |
Human   817 ----------AFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRAST------P 865

  Fly  1346 PTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWVTSKQKYMRLEHDISNIKNW- 1409
            .|.          ..:|.|.:|.:.|                |.:|.:.: .:|..:|..::|.
Human   866 RTT----------TMTFTCFVFFDLF----------------NALTCRSQ-TKLIFEIGFLRNHM 903

  Fly  1410 ------------------PPITEVYEPNNL--ID--------------------CETE--QPTYV 1432
                              ||:..|::..||  :|                    ||..  .|..|
Human   904 FLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRV 968

  Fly  1433 SLHAE 1437
            .:|.|
Human   969 QMHPE 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	192/1023 (19%)
ATP2C2	NP_001273456.2	P-type_ATPase_SPCA	85..956	CDD:319779	219/1212 (18%)