DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp1a2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_848492.1	Gene:	Atp1a2 / 98660	MGIID:	88106	Length:	1020	Species:	Mus musculus

Alignment Length:	1160	Identity:	231/1160 - (19%)
Similarity:	383/1160 - (33%)	Gaps:	378/1160 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWF-------------------TYDYYYYACV 381
            |.|.:|.|....:.:.|...|     |..||::||.                   :.|..|...|
Mouse    74 GPNALTPPPTTPEWVKFCRQL-----FGGFSILLWIGALLCFLAYGILAAMEDEPSNDNLYLGIV 133

  Fly   382 ILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTL 446
            :..:.:.....|..|..|:..::...........:|..:|...::....:|.||::|: ..|..:
Mouse   134 LAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEV-KGGDRV 197

  Fly   447 HCDAILISGN-CILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKK 510
            ..|..:||.: |.:|.|.|||||.|.|::|     :...:.....|:..|..|..::    |:.:
Mouse   198 PADLRIISSHGCKVDNSSLTGESEPQTRSP-----EFTHENPLETRNICFFSTNCVE----GTAR 253

  Fly   511 VLAFVINTGNITAKGEL--IRSILY--PPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRG 571
              ..||.||:.|..|.:  :.|.|.  ..|:..:.|.    |||.:..:|....:...|..::.|
Mouse   254 --GIVIATGDRTVMGRIATLASGLEVGQTPIAMEIEH----FIQLITGVAVFLGVSFFVLSLILG 312

  Fly   572 TDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTG 636
            ...::..:..:.:|...||..|.|.:||......||:........:..::...||.:..|.||||
Mouse   313 YSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 377

  Fly   637 TLTEDGL---DMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKM 698
            |||::.:   .||                      ||:
Mouse   378 TLTQNRMTVAHMW----------------------FDN--------------------------- 393

  Fly   699 FESTGWELEDSNNIPDTEKYGILY----PTILRQPR-GGLSGMAETESGSKN-EIKRQSSVDD-- 755
                  ::.:::...|  :.|..:    ||.....| .||...|..::|.:| .:.::.:..|
Mouse   394 ------QIHEADTTED--QSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDAS 450

  Fly   756 ---LLATVGIS--PSQKNFDHG-IVREFPFTSALQ-RMSVVTRCLSDQVFNVYCKGSPEMLKKLC 813
               ||..:.:|  ..:|..|.. .|.|.||.|..: ::|:..|..|.|...:..||:||.:...|
Mouse   451 ESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRC 515

  Fly   814 K-----------PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMN-----YTKVQRLSREEVE 862
            .           .:.:.|.:.....|....|.|::...      ::|     :.:..:...:|:.
Mouse   516 STILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFC------QLNLPSGKFPRGFKFDTDELN 574

  Fly   863 NNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVIT 924
            ...|.|.||.|.:.:.|....|.:|:   .:|.|:.||:|||:.:||.::|:..||:|...
Mouse   575 FPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGN---- 635

  Fly   925 VHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFT 989
                                                                       ||.|..
Mouse   636 -----------------------------------------------------------ETVEDI 641

  Fly   990 AQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQE 1054
            |                       |...:|.|..          ...:|:..:.|..|
Mouse   642 A-----------------------ARLNIPVSQV----------NPREAKACVVHGSD------- 666

  Fly  1055 CIFAMDGKTWQIVKDYFPEEMEILLTRGS--IYARMSPDQKQALVIELQNLDYCVAMCGDGANDC 1117
                        :||...|:::.:|...:  ::||.||.||..:|...|.....||:.|||.||.
Mouse   667 ------------LKDMTSEQLDEILRDHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS 719

  Fly  1118 GALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQF 1179
            .|||.|..||::..:.:.:   |:.....:...::::..::|||..    |...|...||:|...
Mouse   720 PALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSN 780

  Fly  1180 IS------VMILYSIDSNLTDKQYLYVDLG----------------------------------- 1203
            |.      :.|:.:|...|.....|.:|||
Mouse   781 IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNER 845

  Fly  1204 LISIFAFFFGKTESFDG------MLVEQVPLSSLISSTPL---------------------ASLL 1241
            |||:.....|..::..|      :|.|...|.|.:....|                     ...:
Mouse   846 LISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTTNDLEDSYGQEWTYEQRKV 910

  Fly  1242 LHLTVVTAF----QVTCWVHL----------HQQPW---FKAFEPADEDHLGCFENYTMFCISSF 1289
            :..|..|||    .|..|..|          .||..   ...|...:|..|..|
Mouse   911 VEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAF----------- 964

  Fly  1290 QYIILAFVFSKGAPYRK-PLWSNWPLCLAFIVNLCIIVY-----LVL--YPSDWV 1336
                |::....|...|. ||...|..| ||..:|.|.:|     |:|  ||..||
Mouse   965 ----LSYCPGMGVALRMYPLKVTWWFC-AFPYSLLIFIYDEVRKLILRRYPGGWV 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	231/1160 (20%)
		E1-E2_ATPase	381..621	CDD:278548	54/244 (22%)
		Cation_ATPase	<758..813	CDD:289987	16/58 (28%)
		HAD_like	<1087..1137	CDD:304363	20/52 (38%)
Atp1a2	NP_848492.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	231/1160 (20%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231		10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930