DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and PMA2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_015289.1	Gene:	PMA2 / 856071	SGDID:	S000005957	Length:	947	Species:	Saccharomyces cerevisiae

Alignment Length:	1080	Identity:	218/1080 - (20%)
Similarity:	372/1080 - (34%)	Gaps:	362/1080 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 DLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDF--KTLLFLEVLNPF-YVFQLFSVILW 370
            ||:...:|     ||...|...||..:|.|::.......  |.|:|.  :.|. :|.:..:::..
Yeast   108 DLSTDPAY-----GLTSDEVARRRKKYGLNQMAEENESLIVKFLMFF--VGPIQFVMEAAAILAA 165

  Fly   371 FTYDYYYYA--CVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVP 433
            ...|:....  |.:||::.....:...|.....|.|:||:.||.   .|...|...|:|...:||
Yeast   166 GLSDWVDVGVICALLLLNASVGFIQEFQAGSIVDELKKTLANTA---TVIRDGQLIEIPANEVVP 227

  Fly   434 GDIIEIPSSGCTLHCDAILISGNCIL--DESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFC 496
            |:|::: .||.....|..:::.:|.|  |:|.:||||:...|                     ..
Yeast   228 GEILQL-ESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEK---------------------HY 270

  Fly   497 GTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQ--DSYKFIQFLAIIACVG 559
            |.:|..:..:.:.:....|..||:.|..|.....:.....|:..|.:  :....|..:.:||.:.
Yeast   271 GDEVFSSSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILLVLVIATLL 335

  Fly   560 FIYTL-------VTKILRGTDPVKIAVESLDLITIVVPPALPAAMT----VGRFY-AQKRLKTSE 612
            .::|.       :..|||.|         |.:..|.||..|||.:|    ||..| |:|:....:
Yeast   336 LVWTACFYRTVGIVSILRYT---------LGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQK 391

  Fly   613 IFCISPRSINVAGSINCCCFDKTGTLTEDGLDMW------GVVPKSSTNQFQIPLKSVDRLPFDH 671
            :..|.    ::|| :...|.|||||||::.|.:.      ||.|              |.|
Yeast   392 LSAIE----SLAG-VEILCSDKTGTLTKNKLSLHEPYTVEGVSP--------------DDL---- 433

  Fly   672 FLFGMVTCHSITILNGRMMG-DPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSG 735
                |:|  :....:.:..| |.:|....:|.                 |.||.
Yeast   434 ----MLT--ACLAASRKKKGLDAIDKAFLKSL-----------------IEYPK----------- 464

  Fly   736 MAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREF-PFTSALQRMSVVTRCLSDQVFN 799
                   :|:.:.:..                      |.|| ||....::::.|..  |.:...
Yeast   465 -------AKDALTKYK----------------------VLEFHPFDPVSKKVTAVVE--SPEGER 498

  Fly   800 VYC-KGSPEMLKKLCK-----PQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSR 858
            :.| ||:|..:.|..:     |:.:.:||..:::|.|.:|:|.:.:|                 |
Yeast   499 IVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVA-----------------R 546

  Fly   859 EEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVI 923
            :..|.:.|.||.:...:..:.||.:.||......:|..|:|||    |:.:|::
Yeast   547 KRGEGHWEILGVMPCMDPPRDDTAQTINEARNLGLRIKMLTGD----AVGIAKE----------- 596

  Fly   924 TVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEF 988
                               .|.             .|.||              :|:::.|
Yeast   597 -------------------TCR-------------QLGLG--------------TNIYNAE---- 611

  Fly   989 TAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQ 1053
                                                              .||:....|
Yeast   612 --------------------------------------------------RLGLGGGGD------ 620

  Fly  1054 ECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCG 1118
                 |.|           .|:...:.....:|.:.|..|..:|..|||..|.|||.|||.||..
Yeast   621 -----MPG-----------SELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAP 669

  Fly  1119 ALKVAHAGISL-SETEAS-IASPFTSRNPTISAVLKVIKEGRAAL--VTSFGIFKYMAAYSLVQF 1179
            :||.|..||:: ..|:|: .|:......|.:||::..:|..|...  :.|:.:::...:..|..|
Yeast   670 SLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIF 734

  Fly  1180 ISVMILY---SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLL 1241
            :.:.|..   |:|.||         :..|:|||.....|.::|.......|:...:......|::
Yeast   735 LGLWIAILNNSLDINL---------IVFIAIFADVATLTIAYDNAPYAPEPVKWNLPRLWGMSII 790

  Fly  1242 LHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENY-----TMFCISSFQYIILAFVFSKG 1301
            |.:.:.    :..|:.|...     |.|    :.|..:|:     .||...|.....|.||....
Yeast   791 LGIVLA----IGSWITLTTM-----FLP----NGGIIQNFGAMNGVMFLQISLTENWLIFVTRAA 842

  Fly  1302 APYRKPLWS---NWPLCLA-FIVNLCIIVYLVL--YPSDW 1335
            .|:    ||   :|.|..| |.|::...::.:.  :..:|
Yeast   843 GPF----WSSIPSWQLAGAVFAVDIIATMFTLFGWWSENW 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	218/1080 (20%)
		E1-E2_ATPase	381..621	CDD:278548	60/255 (24%)
		Cation_ATPase	<758..813	CDD:289987	12/56 (21%)
		HAD_like	<1087..1137	CDD:304363	22/51 (43%)
PMA2	NP_015289.1	P-type_ATPase_H	116..903	CDD:319771	215/1067 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910