DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and YPK9

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_014934.1	Gene:	YPK9 / 854466	SGDID:	S000005817	Length:	1472	Species:	Saccharomyces cerevisiae

Alignment Length:	1518	Identity:	473/1518 - (31%)
Similarity:	724/1518 - (47%)	Gaps:	311/1518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SLPNHIEDLKFRNSDVETDDDLHFPGIAA-KNKILKLSWWHSPVDMHYVATESVQPKKSDKVPSN 83
            :|.|...|:.:..:.....|.::..|::: ::.|...|...|..:.....:.|.:.:...:.|.
Yeast   134 TLENTDYDMAWDATPAYEQDRIYGTGLSSRRSSIRSFSRASSLSNAKSYGSFSKRGRSGSRAPQ- 197

  Fly    84 KIKKVENNNTLVNGCSKTSARSVPLLKYNRPDQDGDSEENITSVLEPNVDEIY----------SK 138
              :..||::|.....|.|.:.| .|.:|.       :.|.|...||...|||.          |.
Yeast   198 --RLGENSDTGFVYHSATHSSS-SLSRYT-------TRERIPIELESQTDEILEDESSTHSLESS 252

  Fly   139 DSERLVDDSKPCIG--------------LLNPDQEDQM-----KVCGYRR------------SLM 172
            ||.|...::..  |              .|.||..::.     ....|:|            :..
Yeast   253 DSRRSASENNR--GSFSGHDDVHNQHSEYLKPDYHEKFYPQYAPNLHYQRFYIAEEDLVIGIAAY 315

  Fly   173 RTGFCW-----ACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLVTEDYQGK-------H 225
            :|...|     .|.|||.||:.|:..|..||.:.....:..|.:||.|::..:: |:       .
Yeast   316 QTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKVPLAKAEWVVIENEF-GEFVIQPIDR 379

  Fly   226 KMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSIRIFRCKQ 290
            :.|:.....||...|... ...|...|..:|...:.:...:.:.:.|.            :|..:
Yeast   380 QWYNRPLSTVLPFENYPN-PSYEPNDINLSHHHANEINPNVPILITFE------------YRYIK 431

  Fly   291 LVYA-----WNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFKTL 350
            .:|:     :..|.|.... :.:||:.      ...||....|..|.:.||.|:|.:.::....:
Yeast   432 FIYSPLDDLFKTNNNWIDP-DWVDLST------VSNGLTKGVQEDRELAFGKNQINLRMKTTSEI 489

  Fly   351 LFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKK-------------NQD 402
            ||.|||:||||||:||:|||...:|||||..|.|:||..|..|:.:.||             :..
Yeast   490 LFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISVLSIFDSLNEQKKVSRNLAEMSHFHCDVR 554

  Fly   403 VLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCT-LHCDAILISGNCILDESMLTG 466
            ||:...:.|              :.:..:|||||.|:.....| |.||:||:|.:||::||||||
Yeast   555 VLRDKFWTT--------------ISSSELVPGDIYEVSDPNITILPCDSILLSSDCIVNESMLTG 605

  Fly   467 ESVPVTKTPLPSKRDMIFDKTEHARHT----------LFCGTKVIQTRYI-GSKKVLAFVINTGN 520
            |||||:|  .|:..:.::...:..:.|          |:.||.:|:.|.. |....||.|:.||.
Yeast   606 ESVPVSK--FPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIAPGQTAALAMVVRTGF 668

  Fly   521 ITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLI 585
            .|.||.|:||:::|.|..:||.:||:|:|.|:::||..||..:.|..|..|.|...:.:.:||:|
Yeast   669 STTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKLGLDKKTMILRALDII 733

  Fly   586 TIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWG--- 647
            ||||||||||.:|:|..:|..|||...||||||..:|::|.|:..||||||||||||||:.|
Yeast   734 TIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKTGTLTEDGLDVLGVQI 798

  Fly   648 --------------------VVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGD 692
                                |.||.|.|....||....|    :|...::||||:..::|.::||
Yeast   799 SEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSR----NFFMSLLTCHSLRSVDGNLLGD 859

  Fly   693 PLDLKMFESTGWELEDSNNIPDTEK--YGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDD 755
            |||.|||:.|||..|:     |.:|  :..||                 |...::::..::|  :
Yeast   860 PLDFKMFQFTGWSFEE-----DFQKRAFHSLY-----------------EGRHEDDVFPENS--E 900

  Fly   756 LLATVGISPSQKNFDH-----------GIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEML 809
            ::..| :.|...|.::           |:||.|.|.|.|:||||:.:..:|.|:..:.||:||::
Yeast   901 IIPAV-VHPDSNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVI 964

  Fly   810 KKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILE 874
            .::|...:||.::.:.|..:...|||:||.|.|.|. |..:...|::||||||:|:|||||:|.:
Yeast   965 SEICNKSTLPADFEEVLRCYTHNGYRVIACAGKTLP-KRTWLYSQKVSREEVESNLEFLGFIIFQ 1028

  Fly   875 NRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTN 939
            |:||.:|::.:.:|..|.|||||.|||||||||||.|:.|::..|:    |:...|.|:
Yeast  1029 NKLKKETSETLKSLQDANIRTIMCTGDNILTAISVGREAGLIQCSR----VYVPSINDT------ 1083

  Fly   940 TGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNS 1004
                           .||                                   |:.:.....
Yeast  1084 ---------------PLH-----------------------------------GEPVIVWRD--- 1095

  Fly  1005 LVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIV-- 1067
             |||..                 |.:||.|....:||  :...||.|......|:.|..::::
Yeast  1096 -VNEPD-----------------KILDTKTLKPVKLG--NNSVESLRECNYTLAVSGDVFRLLFR 1140

  Fly  1068 -KDYFPEEM--EILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISL 1129
             ::..|||.  |||| ..|||||||||:|..|:|:||.|||.|..||||||||||||.|..||||
Yeast  1141 DENEIPEEYLNEILL-NSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISL 1204

  Fly  1130 SETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTD 1194
            ||.|||:|:||||:...||.||.||:||||||||||..|:||:.||.:|||::.||||..|||.|
Yeast  1205 SEAEASVAAPFTSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGD 1269

  Fly  1195 KQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLH 1259
            .|:||:||.||...|.....::|:: .:.::.|.::|:|...|..||:.:.:|..||...|:.:.
Yeast  1270 FQFLYIDLLLIVPIAICMSWSKSYE-KIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQ 1333

  Fly  1260 QQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCI 1324
            :..|:.......:|.:...:|..:|.:|:||||:.|.|.|.|.|||:|:..|:    .|||::.:
Yeast  1334 KMSWYIKPIVGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKNF----EFIVDITV 1394

  Fly  1325 -----IVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVK 1384
                 ::.:.|....::....|| .|.:..|...::.:...::...:::...:..:|..||
Yeast  1395 SIGASLLLMTLDTESYLGKMLQL-TPISNSFTMFIIVWVILNYYAQLYIPPSIKGWLKKKK---- 1454

  Fly  1385 REKNWVTSKQKYMRLEHDISNIK 1407
                   |.:||..|..:...:|
Yeast  1455 -------SSKKYKLLIQEEMKLK 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	28/161 (17%)
		P-ATPase-V	173..1355	CDD:273738	430/1269 (34%)
		E1-E2_ATPase	381..621	CDD:278548	99/264 (38%)
		Cation_ATPase	<758..813	CDD:289987	20/65 (31%)
		HAD_like	<1087..1137	CDD:304363	36/49 (73%)
YPK9	NP_014934.1	P-ATPase-V	307..1431	CDD:273738	430/1280 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343814
Domainoid	1	1.000	229	1.000	Domainoid score	I415
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23455
Inparanoid	1	1.050	653	1.000	Inparanoid score	I105
Isobase	1	0.950	-	0	Normalized mean entropy	S1582
OMA	1	1.010	-	-		QHG54176
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		oto99015
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	LDO	PTHR45630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R101
SonicParanoid	1	1.000	-	-		X554
TreeFam	1	0.960	-	-
	16	15.740