DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and ENA2

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_010324.3	Gene:	ENA2 / 851609	SGDID:	S000002446	Length:	1091	Species:	Saccharomyces cerevisiae

Alignment Length:	1309	Identity:	246/1309 - (18%)
Similarity:	462/1309 - (35%)	Gaps:	397/1309 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 NNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQISRRIVFGDNEITVPLR-DFKTLLFLEVLNP 358
            ||...|...:.|.......:....  .||...|.:.|....|:|.:....: |:|.::..:|.|.
Yeast     9 NNNEEFNAYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNA 73

  Fly   359 FYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKTV-----YNTGNAWVVD 418
            ..:..:.|:.:.|....:....||..:....:.:.::|..|    ..||:     .::.||.|:
Yeast    74 MIMVLVISMAISFAVRDWITGGVISFVIAVNVLIGLVQEYK----ATKTMNSLKNLSSPNAHVI- 133

  Fly   419 HKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILI-SGNCILDESMLTGESVPVTKTPLPSKRDM 482
            ..|.|:.:.::.:|||||. :...|.|:..|..|| :.|...|||:|||||:||:|     ..::
Yeast   134 RNGKSETINSKDVVPGDIC-LVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSK-----DANL 192

  Fly   483 IFDKTEHAR-----HTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSI-----LYPPPV 537
            :|.|.|...     :..|..:.|::.|..|      .||.|...:..|::.:|:     |.....
Yeast   193 VFGKEEETSVGDRLNLAFSSSAVVKGRAKG------IVIKTALNSEIGKIAKSLQGDSGLISRDP 251

  Fly   538 DYKFEQDSY---------------------KFIQFLAIIACVGFIYTLVTKILRGTDPVK-IAVE 580
            ...:.|:::                     |..:...::..:..::.::....:..|..| :|:.
Yeast   252 SKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIY 316

  Fly   581 SLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGL-- 643
            ::.:...::|.:|...:|:........:.:..:......|:...|::|..|.|||||||:..:
Yeast   317 AICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLA 381

  Fly   644 -DMWGVVPK-------SSTNQFQIPLKSVDRLP-FDHFLFGMVTCHSITILNG-------RMMGD 692
             .:|  :|:       :|.:.|.....:|..:| |..:.:.......:.||..       :.:.:
Yeast   382 RQIW--IPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPE 444

  Fly   693 PLDLKMFESTGWELEDSN--NIP---------------DTEKYGI-LYPTILRQPRGGLSGMAET 739
            .:|:.:|:.  | ||.:.  ||.               |..:..| ::.|.:..|...|:|...|
Yeast   445 DIDMDLFQK--W-LETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKST 506

  Fly   740 ESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKG 804
            ...::|:   |||    |:.....|....|:|  :.||||.|.::|||.|.....::.:|:|.||
Yeast   507 NQSNEND---QSS----LSQHNEKPGSAQFEH--IAEFPFDSTVKRMSSVYYNNHNETYNIYGKG 562

  Fly   805 SPEMLKKLC---------KPQSLPD----NYSQQLSEFAKKGYRIIAIAFKALS-HKMNYTKVQR 855
            :.|.:...|         |...|.|    ...:.:...:.:|.|::..|.|:.: .::|..:::.
Yeast   563 AFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKN 627

  Fly   856 L--SREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSP 918
            :  :|...|:::.|||.:.:.:..:.:|...:...:.|.|...|:|||.:.||.::|::.||
Yeast   628 ITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGI--- 689

  Fly   919 SQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDP 983
                             :.||.               .||:
Yeast   690 -----------------LPTNL---------------YHYS------------------------ 698

  Fly   984 ETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDE 1048
                           .|..:|:|
Yeast   699 ---------------QEIVDSMV------------------------------------------ 706

  Fly  1049 SWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDG 1113
                      |.|..:..:.:   ||::.|.....:.||.||..|..::..|.......||.|||
Yeast   707 ----------MTGSQFDGLSE---EEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDG 758

  Fly  1114 ANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYS 1175
            .||..:||:|:.||::....:.:   ||.....:...:::|..::|||                .
Yeast   759 VNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGR----------------R 807

  Fly  1176 LVQFISVMILYSIDSNLTDKQYLYVDLGLI-------SIF-------AFFFGKTESFDGM----- 1221
            :...|...:|..:..|:.  |.||:.:||:       |:|       .:....|..|..|
Yeast   808 MTDNIQKFVLQLLAENVA--QALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLE 870

  Fly  1222 -----LVEQVPLSS--------LISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADED 1273
                 |:::.|..|        :|..|....:::..:.:.:|..:.:             ..:..
Yeast   871 KAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLY-------------GINSG 922

  Fly  1274 HLG--CFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWV 1336
            .||  |...|...|...::        |:.|.:....|             |.:: |.....|..
Yeast   923 RLGHDCDGTYNSSCRDVYR--------SRSAAFATMTW-------------CALI-LAWEVVDMR 965

  Fly  1337 ASFFQLIVPPT-------------MRFRYVMLAYGAASFICHIFVESFLVEYL------VFKKYQ 1382
            .|||:: .|.|             .:|.:..:.:|        ||.:|.|.|:      ||....
Yeast   966 RSFFRM-HPDTDSPVKEFFRSIWGNQFLFWSIIFG--------FVSAFPVVYIPVINDKVFLHKP 1021

  Fly  1383 VKREKN---------WV------TSKQKYMRLE--HDISNIKNWPPITEVYEPNNLIDCETEQPT 1430
            :..|..         |:      ..|::|.:.:  |:..|         ..|.||..|......|
Yeast  1022 IGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNPEN---------DLESNNKRDPFEAYST 1077

  Fly  1431 YVSLHAEQN 1439
            ..::|.|.|
Yeast  1078 STTIHTEVN 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	224/1200 (19%)
		E1-E2_ATPase	381..621	CDD:278548	54/277 (19%)
		Cation_ATPase	<758..813	CDD:289987	17/54 (31%)
		HAD_like	<1087..1137	CDD:304363	17/52 (33%)
ENA2	NP_010324.3	ATPase-IID_K-Na	11..1055	CDD:130586	234/1265 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910