DRSC/TRiP Functional Genomics Resources

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Protein Alignment anne and ATP8B4

DIOPT Version :9

Sequence 1:NP_001096849.1 Gene:anne / 317815 FlyBaseID:FBgn0052000 Length:1451 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1306 Identity:265/1306 - (20%)
Similarity:466/1306 - (35%) Gaps:424/1306 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 CSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVH--EQISRRIVFGDNEITV 342
            ||..::...:::|.|  |:....::....|..|..|.|:....||::  ||..|          |
Human    40 CSEKKLREVERIVKA--NDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQR----------V 92

  Fly   343 PLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKT 407
            ....|..||.|:::..      .|.:.||| .......||.:.:|...|....:.|.:..|    
Human    93 ANAYFLCLLILQLIPE------ISSLTWFT-TIVPLVLVITMTAVKDATDDYFRHKSDNQV---- 146

  Fly   408 VYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILIS-----GNCILDESMLTG- 466
              |...:.|:.:..|..|......| ||||::.::. .:..|.:|:|     |.|.::.:.|.| 
Human   147 --NNRQSEVLINSKLQNEKWMNVKV-GDIIKLENNQ-FVAADLLLLSSSEPHGLCYVETAELDGS 207

  Fly   467 ----ESVPVTKTPLPSKRDMI--FDKTE---HARHTL---------------FCGTKVIQT---- 503
                :.||..:..|...::.:  |.|.|   ..||.|               |.|..|.:.    
Human   208 LCCYKDVPWVECQLFGAQEALPTFLKQETNLKVRHALSVTSELGADISRLAGFDGIVVCEVPNNK 272

  Fly   504 --RYIG--SKKVLAFVINTGNITAKGELIRS-------ILYPPPVDYKFEQDSYK---------- 547
              :::|  |.|.....:|...|..:|.::|:       :::..| |.|..|:|.|          
Human   273 LDKFMGILSWKDSKHSLNNEKIILRGCILRNTSWCFGMVIFAGP-DTKLMQNSGKTKFKRTSIDR 336

  Fly   548 -----FIQFLAIIACVGFIYTLVTKI------------LRGTDPVKIAVES--------LDLITI 587
                 .:.....:.|:|.|..:...|            |...:..|.:|.|        :.::..
Human   337 LMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNT 401

  Fly   588 VVPPALPAAMTVGR-------------FYAQKRL----KTSEIFCISPRSIN-VAGSINCCCFDK 634
            |||.:|..::.|.|             :|::|.:    :|:        ::| ..|.|.....||
Human   402 VVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTT--------TLNEELGQIEYIFSDK 458

  Fly   635 TGTLTE-------------------DGLDMWGVVPKSSTNQFQIPL-----KSVDR--LPFDHFL 673
            |||||:                   |.||.     |:...|.:.|:     ...||  ..|||.|
Human   459 TGTLTQNIMTFKRCSINGRIYGEVHDDLDQ-----KTEITQEKEPVDFSVKSQADREFQFFDHHL 518

  Fly   674 FGMVTCHSITILNGRMMGDPL---DLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSG 735
            ...:           .||||.   .|::.......:.:.|:..:     ::|.  ::.|..|...
Human   519 MESI-----------KMGDPKVHEFLRLLALCHTVMSEENSAGE-----LIYQ--VQSPDEGALV 565

  Fly   736 MAETESG--SKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVF 798
            .|....|  .|:......::::|...|         .:.::....|.:..:||||:.|....|: 
Human   566 TAARNFGFIFKSRTPETITIEELGTLV---------TYQLLAFLDFNNTRKRMSVIVRNPEGQI- 620

  Fly   799 NVYCKGSPEMLKKLCKPQS--LPDNYSQQLSEFAKKGYRIIAIAFKALS-------HKM----NY 850
            .:|.||:..:|.:...|.:  |....|..|||||.:|.|.:|||::.|.       |||    |.
Human   621 KLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANA 685

  Fly   851 TKVQRLSR-----EEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVA 910
            ...:|..|     ||:|.::..||...:|::|:....:.:.:|:.|.|:..::|||...|||::.
Human   686 ATEERDERIAGLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIG 750

  Fly   911 RDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSC 975
            ..|.:::          |.:.|...|..|...|.                       |..|.|: 
Human   751 YACNMLT----------DDMNDVFVIAGNNAVEV-----------------------REELRKA- 781

  Fly   976 FNSNLFDPETPEFTAQVGKTIFHME---STNSLVNES-TSSYAESGLPTSDSLASVKTIDTWTHN 1036
             ..|||. :...|:.  |..:...:   ..:|:|.|: |..||.  :....|||  ..:::...|
Human   782 -KQNLFG-QNRNFSN--GHVVCEKKQQLELDSIVEETITGDYAL--IINGHSLA--HALESDVKN 838

  Fly  1037 D-AELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIEL 1100
            | .||.             |                       :.:..|..|::|.||..:|..:
Human   839 DLLELA-------------C-----------------------MCKTVICCRVTPLQKAQVVELV 867

  Fly  1101 QNLDYCVAMC-GDGANDCGALKVAHAGISLSETE---ASIASPFTSRNPTISAVLKVIKEGRAAL 1161
            :.....|.:. ||||||...:|.||.|:.:|..|   |.:||.::      .|..:.::  |..|
Human   868 KKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYS------FAQFRYLQ--RLLL 924

  Fly  1162 V----TSFGIFKYMA-------AYSLVQF----------------------------ISVMILYS 1187
            |    :.|.:.|::.       |::||.|                            :.|:.:..
Human   925 VHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGI 989

  Fly  1188 IDSNLTD----------------------KQYLYVDLGLISIFAFFFGKTESF------DGMLVE 1224
            .|.:::|                      |.::.|..|:.:....||....:|      ||..:.
Human   990 FDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIA 1054

  Fly  1225 QVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSF 1289
            .....::..:|   ||::.::|..|...:.|..:              :|:..:.:..::     
Human  1055 DYQSFAVTMAT---SLVIVVSVQIALDTSYWTFI--------------NHVFIWGSIAIY----- 1097

  Fly  1290 QYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNL-------CIIVYLVLYPSDWVASFFQLIVPPT 1347
             :.||..:.|.|      ::..:|....|:.|.       ||.:.::|   ..|||     |.|.
Human  1098 -FSILFTMHSNG------IFGIFPNQFPFVGNARHSLTQKCIWLVILL---TTVAS-----VMPV 1147

  Fly  1348 MRFRYV 1353
            :.||::
Human  1148 VAFRFL 1153

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
anneNP_001096849.1 P5-ATPase 158..291 CDD:289194 2/10 (20%)
P-ATPase-V 173..1355 CDD:273738 265/1306 (20%)
E1-E2_ATPase 381..621 CDD:278548 64/336 (19%)
Cation_ATPase <758..813 CDD:289987 12/54 (22%)
HAD_like <1087..1137 CDD:304363 19/53 (36%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 19/82 (23%)
ATPase-Plipid 65..1167 CDD:273734 260/1279 (20%)
Cation_ATPase 538..634 CDD:289987 20/112 (18%)
HAD_like <875..906 CDD:304363 12/30 (40%)
PhoLip_ATPase_C 906..1160 CDD:292829 47/293 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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