Protein Alignment anne and ATP13A3

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001354478.1
• Gene: ATP13A3 / 79572
• HGNCID: 24113
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 1336
• Identity: 510/1336 - (38%)
• Similarity: 743/1336 - (55%)
• Gaps: 190/1336 - (14%)

  Fly   154 LNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHW---WRHLYLYATCSQCSLEEAEQV 215
            :|..|||:|::.||..|..:.......:..:||.|.|:|:|   ||   :.|||.:.::::.|.|
Human     9 INQGQEDEMEIYGYNLSRWKLAIVSLGVICSGGFLLLLLYWMPEWR---VKATCVRAAIKDCEVV 70

  Fly   216 LV--TEDYQGKHKMYHVKQIQVLT-----SSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFT 273
            |:  |:::    ||:...:|:||:     .|:.|::..|    :...|..| .:||..:.:.|..
Human    71 LLRTTDEF----KMWFCAKIRVLSLETYPVSSPKSMSNK----LSNGHAVC-LIENPTEENRHRI 126

  Fly   274 SAQFKKCSS--IRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCS--YYHQQRGLPVHEQISRRIV 334
            | ::.:..|  ||.|....:.|.||:..:.|..:.|||..:.|:  |.....||.......|:::
Human   127 S-KYSQTESQQIRYFTHHSVKYFWNDTIHNFDFLKGLDEGVSCTSIYEKHSAGLTKGMHAYRKLL 190

  Fly   335 FGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKK 399
            :|.|||.|.:.....||..|||||||:|||||||||.|.:|||||..|::||:..|..|:...:|
Human   191 YGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSTDEYYYYALAIVVMSIVSIVSSLYSIRK 255

  Fly   400 NQDVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDES 462
            ...:|...|  ::|....|.......:|:.:..:||||::.||.:|..:.|||:||:|.||::||
Human   256 QYVMLHDMVATHSTVRVSVCRVNEEIEEIFSTDLVPGDVMVIPLNGTIMPCDAVLINGTCIVNES 320

  Fly   463 MLTGESVPVTKTPLPSKR-------DMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGN 520
            ||||||||||||.||:..       |.:::...|.||||||||.|||||:...:.|.|.|:.||.
Human   321 MLTGESVPVTKTNLPNPSVDVKGIGDELYNPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGF 385

  Fly   521 ITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLI 585
            .|:||:|:||||||.|.|:|..:|:|.|:..|..:|.:|||||::..||.......|.:||||:|
Human   386 STSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVAVAGIGFIYTIINSILNEVQVGVIIIESLDII 450

  Fly   586 TIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVP 650
            ||.||||||||||.|..|||:|||...||||||:.||:.|.:|..||||||||||||||:|| :.
Human   451 TITVPPALPAAMTAGIVYAQRRLKKIGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWG-IQ 514

  Fly   651 KSSTNQFQIPLKSV--DRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIP 713
            :....:|..|.::|  :.|....|:..|.||||:|.:.|.:.||||||||||:.||.||::.. .
Human   515 RVENARFLSPEENVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEEATE-E 578

  Fly   714 DTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFP 778
            :|..:..:.||::|.|:..|.  ..|.:|:     ::..:.:|.||         ::.||||:||
Human   579 ETALHNRIMPTVVRPPKQLLP--ESTPAGN-----QEMELFELPAT---------YEIGIVRQFP 627

  Fly   779 FTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKA 843
            |:|||||||||.|.|.|:..:.|.||:||.:..||||:::|.::...|.:|.|:|:|:||:|.:.
Human   628 FSSALQRMSVVARVLGDRKMDAYMKGAPEAIAGLCKPETVPVDFQNVLEDFTKQGFRVIALAHRK 692

  Fly   844 LSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAIS 908
            |..|:.:.|||.:||:.:||||:|:|.:|::|:||.:|..|:..|:.|.|||:|:|||::|||:|
Human   693 LESKLTWHKVQNISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDSMLTAVS 757

  Fly   909 VARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFK 973
            ||||||::.|...||...|.|..|....:.|                .||...|          .
Human   758 VARDCGMILPQDKVIIAEALPPKDGKVAKIN----------------WHYADSL----------T 796

  Fly   974 SCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDA 1038
            .|.:.:..|||.      :...:.|                       |||           .|.
Human   797 QCSHPSAIDPEA------IPVKLVH-----------------------DSL-----------EDL 821

  Fly  1039 ELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNL 1103
            ::...|            |||:||::.::.::|.:.:..|:..|:::|||:||||..|:..|||:
Human   822 QMTRYH------------FAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLIEALQNV 874

  Fly  1104 DYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIF 1168
            ||.|.|||||||||||||.||.||||||.|||:||||||:.|:||.|..:|:||||||:|||.:|
Human   875 DYFVGMCGDGANDCGALKRAHGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALITSFCVF 939

  Fly  1169 KYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLIS 1233
            |:||.||::|:.||.:||||.|||.|.|:|::||.:|.:..|......::. .||.|.|.|.|||
Human   940 KFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPAWK-ELVAQRPPSGLIS 1003

  Fly  1234 STPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEP-----------------------ADEDHL 1275
            ...|.|:|..:.:...||...:..:.||||::.:.|                       .||.::
Human  1004 GALLFSVLSQIIICIGFQSLGFFWVKQQPWYEVWHPKSDACNTTGSGFWNSSHVDNETELDEHNI 1068

  Fly  1276 GCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSDWVASFF 1340
            ..:||.|:|.||||||:|:|..||||.|:|:|.:.|:....:.|.....|::::|||...|....
Human  1069 QNYENTTVFFISSFQYLIVAIAFSKGKPFRQPCYKNYFFVFSVIFLYIFILFIMLYPVASVDQVL 1133

  Fly  1341 QLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKN----------------- 1388
            |::..| .::|..||.....:....|.||:|.:: :|..|....|:|.
Human  1134 QIVCVP-YQWRVTMLIIVLVNAFVSITVENFFLD-MVLWKVVFNRDKQGEYRFSTTQPPQESVDR 1196

  Fly  1389 -------WV------TSKQKYMRLEHDISNIKNWPP 1411
                   |.      |.|.|||.|..::.....|||
Human  1197 WGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPP 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	41/149 (28%)
		P-type_ATPase_cation	326..1281	CDD:319842	410/988 (41%)
ATP13A3	NP_001354478.1	P-ATPase-V	14..1149	CDD:273738	490/1245 (39%)