DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp13a-like

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_004914468.2	Gene:	atp13a-like / 733496	XenbaseID:	XB-GENE-5883964	Length:	1245	Species:	Xenopus tropicalis

Alignment Length:	1347	Identity:	430/1347 - (31%)
Similarity:	678/1347 - (50%)	Gaps:	196/1347 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 GLLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVL 216
            |::|...|::.:|.|||....|...|:....|:.||:|.:|:|.:.:|::..|:.||||||:.:|
Frog    11 GIVNEGSENEFQVFGYRTKRWRQALCYVGYVLSLGLIRFLLYWKQEMYVWFVCNPCSLEEADILL 75

  Fly   217 V-TEDYQ-----GKHKMYHVKQIQVLTSSNLKTLLEKEQQSIERTHIECDHVENVLQLSVHFTSA 275
            : |.|.|     .|.|.:||..:..:...|..|..:|:.:.:.                   .:.
Frog    76 LRTTDEQKKCCMKKVKSFHVANVSHIAYMNNNTAEKKDSKELP-------------------VNT 121

  Fly   276 QFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQISRRIVFGDN 338
            :.|    :|....:::.|.||.....||:...||....||..|.:  .|....||.:||.:.|.|
Frog   122 ELK----VRYMHVQKMRYIWNPFRGTFQKSGVLDDTHSCSDIHTKFASGFSKEEQDNRRQICGSN 182

  Fly   339 EITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKKNQDV 403
            .|.|.:.....|||.|:|||.|.|:.:::|||.:..|..|:..||::::..|..:|...:.....
Frog   183 SIEVEITPIWKLLFREILNPVYCFEAYALILWLSAGYIEYSMAILILTILSIIATVTLLRMQSVK 247

  Fly   404 LQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDESMLTG 466
            |.|.|  :|.....|:...|..:|:.::.:||||:|.:|.....|.||||||||.|:::|.||||
Frog   248 LHKMVEFHNNVMVTVLRKTGDIEEVQSQNLVPGDVIILPEKKMYLPCDAILISGGCVINEGMLTG 312

  Fly   467 ESVPVTKTPLPSKRDMI----FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGEL 527
            |.|||||||||...:.|    :....:..|.|:|||:|.:|:......|.|.|::||..|.||:|
Frog   313 ECVPVTKTPLPCVDNCIPWNVYTGDNYKEHMLYCGTEVTKTKPDSDGLVKAVVLHTGFNTTKGDL 377

  Fly   528 IRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPA 592
            :||||||.|:.:|..:|.:..|..|::::..|.||::|...|:|.:|..:.:....::|..||.:
Frog   378 VRSILYPKPIKFKLYKDVFWVIAALSVVSVFGLIYSVVVGALQGAEPKDLVLMGFIMLTCAVPVS 442

  Fly   593 LPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQF 657
            ||.|:.|...|:|.|||...||||||..|::.|.:|..||||||||||:|||:||:|| |..|.|
Frog   443 LPPALAVCVLYSQNRLKKHGIFCISPDRISLCGQLNLICFDKTGTLTEEGLDLWGIVP-SRENCF 506

  Fly   658 QIP--LKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGI 720
            |..  ..|...||:...|..:.:|||:.:|:|.:.|||||.||||.:||.:::|......:
Frog   507 QEAHHFTSGSTLPWGPLLGAVASCHSLIVLDGAIHGDPLDFKMFEGSGWNIDESQATCTVD---- 567

  Fly   721 LYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQR 785
                      |........:.||.:::    .||      ||:         |:.:|||:|||||
Frog   568 ----------GKCCSCVTVKPGSGSKV----PVD------GIN---------ILLQFPFSSALQR 603

  Fly   786 MSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNY 850
            ||||.:.:.:|...::.||:|||:.:.||.:::|.::...|..:.::|:|:|::|:|....:.|.
Frog   604 MSVVAQVIGEQRLTLFLKGAPEMVVRFCKQETVPSSFKNTLDYYTEQGFRVISLAYKYFELEENI 668

  Fly   851 TKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGI 915
            : :..|.|||||:::.||||:|:||:|||:|..|:..|.:|.:||:|:||||:.||.:|....|:
Frog   669 S-LPNLKREEVESDLIFLGFLIMENQLKPETKPVLQELVSANLRTVMLTGDNLKTACTVGMGSGM 732

  Fly   916 VSPSQSVITVHADPIGD------------------------SANIQ-TNTGTECNFDNSSDKHYK 955
            |..:.:|..:.|....:                        :.||. |:...:||...:     |
Frog   733 VPSTDNVFLLEATEYEEGTQPFINWQILKRNKDNDTKLNETTVNILCTDNAIKCNTIQN-----K 792

  Fly   956 LHYTLDLGSKTSRAYLFKSCFNSNLFDPE--------TPEFTAQVGKTIFHMESTNSLVNESTSS 1012
            |.|.      ||..|.  |....||  ||        .|...|.|.      .|..::....|..
Frog   793 LDYA------TSGTYY--STDKQNL--PELMMPNVCLLPSVFADVA------PSVAAVAFSKTGE 841

  Fly  1013 YAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEI 1077
            ..:|..|:|..:                          ::.:..:||.|.::|.:|.:||:.|..
Frog   842 NIQSESPSSHYI--------------------------KQHKYHYAMTGNSYQTIKQHFPDLMPD 880

  Fly  1078 LLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTS 1142
            :|..|:|:|||:|.||..::.:|||:||.|.|||||||||||||:|||||||||.|||:||||||
Frog   881 ILLNGTIFARMTPKQKSTMIEDLQNIDYYVGMCGDGANDCGALKMAHAGISLSELEASVASPFTS 945

  Fly  1143 RNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGL-IS 1206
            :...|:.:..::||||...||...:||||..|:.:..|.:.:::...:.|...|||..|:.: |.
Frog   946 KITNITCMPILLKEGRNVFVTYISLFKYMVMYAFIGLICMFLMFWEQTILGSNQYLMQDIAITIP 1010

  Fly  1207 IFAFFFGKTESFDG---MLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFE 1268
            :..     |.|.:|   .|....|...|:....|.|::|||:.....|:..:..|.|||||...:
Frog  1011 LML-----TLSLNGPAPKLAPYRPAGRLLLPPLLLSIILHLSFTLTVQMCAYFVLQQQPWFSRTD 1070

  Fly  1269 -----------------PADEDHLGCFENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCL 1316
                             |.:.|....|...|.:.|:....||:.||||||.|:|:|:::|:...:
Frog  1071 VFYACIPQNMSFANQTSPMEYDISQNFFTSTCWLITGINLIIIEFVFSKGRPFRQPIYTNYIFLM 1135

  Fly  1317 AFIVNLCIIVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVE-----YL 1376
            ..:..:.:.::.:....:.:.|..:.:..| ..:|.::.|...|.|....|:|..::|     ..
Frog  1136 LVVAQVAVYMFFLFADIESLYSALKFVCMP-YYWRGIIFAMVFALFAVSYFIEECILENRSLWLR 1199

  Fly  1377 VFKKYQVKREKNWVTSKQKYMRLEHDISNIKNWPPIT--EVYEPNNL 1421
            ::|.:..|...::   |:....||     :.|.|.:.  :.|..|.|
Frog  1200 IYKMFNCKYLSHF---KELQKALE-----MNNHPSVVPRKTYRTNAL 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	34/138 (25%)
		P-ATPase-V	173..1355	CDD:273738	407/1251 (33%)
		E1-E2_ATPase	381..621	CDD:278548	95/245 (39%)
		Cation_ATPase	<758..813	CDD:289987	21/54 (39%)
		HAD_like	<1087..1137	CDD:304363	36/49 (73%)
atp13a-like	XP_004914468.2	P5-ATPase	17..138	CDD:403569	35/143 (24%)
atp13a-like	XP_004914468.2	P-type_ATPase_cation	170..1066	CDD:319842	345/982 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47549
Panther	1	1.100	-	-	O	PTHR45630
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110