Protein Alignment anne and Atp2c2

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_081198.1
• Gene: Atp2c2 / 69047
• MGIID: 1916297
• Length: 944
• Species: Mus musculus
• Alignment Length: 1171
• Identity: 223/1171 - (19%)
• Similarity: 392/1171 - (33%)
• Gaps: 373/1171 - (31%)

  Fly   221 YQGKHKMYHVKQIQVLTSSNLKTLLEK--EQQSIERTHIECDHVENVLQLSVHFTSAQFKKCSSI 283
            :.|::..|     :.|....::||:::  |.::|||.       :.|..|    ...:..|||.
Mouse    13 FLGQNHRY-----KALERDEVETLIDEQCELKAIERE-------KTVAAL----PPGEACKCSR- 60

  Fly   284 RIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFK 348
                 ::|..|::           :||:         .||.......||:|.|.||......:..
Mouse    61 -----EELARAFH-----------VDLD---------SGLSEFAVAQRRLVHGWNEFVTDNAEPV 100

  Fly   349 TLLFLEVL-NPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQ---TKKNQDVLQKTVY 409
            ...:|:.. ||..:..|.|.::......|..|..|.|..:..:||..:|   ::|:.:.|.|.|.
Mouse   101 WKKYLDQFRNPLILLLLGSSVVSVLTKEYEDAVSIALAVLIVVTVGFIQEYRSEKSLEELTKLVP 165

  Fly   410 NTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILIS-GNCILDESMLTGESVPVTK 473
            ...|..   ..|..:.:..|.:|||||:.: |.|..:..|..|.. .:.::|||..|||..|..|
Mouse   166 PECNCL---RDGKLRHMLARDLVPGDIVSL-SMGDRIPADIRLTEVTDLLVDESSFTGEVEPCGK 226

  Fly   474 T--PLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPP 536
            |  ||....|:     ....:.:|.||      .:...|....||.||..:..||:.:.:.....
Mouse   227 TDSPLADGGDL-----STLSNVVFMGT------LVQCGKGQGVVIGTGEQSQFGEVFKMMRAEET 280

  Fly   537 VDYKFEQDSYKFIQFLAIIA--CVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTV 599
            .....::...|..:.|.|.:  .:|.:  ::...::|...:.:....:.|....:|..||..:.|
Mouse   281 PKTPLQKSMDKLGKQLTIFSFGIIGLL--MLVGWVQGKPFLSMFTVGVSLAVAAIPEGLPIVVMV 343

  Fly   600 GRFYAQKRLKTSEIFCISPRSINVAGSINCC---CFDKTGTL-----------TEDGL--DMWGV 648
            .......|:....:..   :.:.:..::.||   |.||||||           |.||.  ::.||
Mouse   344 TLVLGVLRMAKKRVIV---KKLPIVETLGCCNVICSDKTGTLTANEMTATQLVTSDGFHAEVSGV 405

  Fly   649 VPKSSTNQFQIPLKSVDRLPFDHFLFGMV-----TCHSITILNGRMMGDPLDLKMFESTGWELED 708
            ..........:|.|.|.: .||:...|.:     ..::..|....:||.|.:
Mouse   406 GYSGEGTVCLLPSKEVIK-GFDNVSVGKLVEAGCVANNAVIRKNAVMGQPTE------------- 456

  Fly   709 SNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGI 773
                      |.|....::...|.:          |:...|:
Mouse   457 ----------GALVVLAMKMNLGSI----------KDSYVRK----------------------- 478

  Fly   774 VREFPFTSALQRMSVVTRC--LSDQVFNVY-CKGSPEMLKKLCK------------PQSLPDNYS 823
             :|.||:|..:.|:|  ||  .|:...::| .||:.|.:...|.            ||.  .:|.
Mouse   479 -KEIPFSSEQKWMAV--RCGPKSEDGEDIYFMKGAFEEVIHHCSMYNNGGIPLPLTPQQ--KSYC 538

  Fly   824 QQ-LSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINA 887
            || ..:....|.|::|:|                |..|: ..:.|||.|.:.:..:....:.:..
Mouse   539 QQEEKKMGSLGLRVLALA----------------SGPEL-GRLTFLGLVGIIDPPRAGVKEAVQV 586

  Fly   888 LNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDK 952
            |:.:.:...|:|||.:.||:::.|..|:                            ||
Mouse   587 LSESGVSVKMVTGDALETALAIGRTIGL----------------------------CN------- 616

  Fly   953 HYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESG 1017
                                             .:..|..|:.:           |.|    |.|
Mouse   617 ---------------------------------EKLKAMSGEEV-----------EGT----EQG 633

  Fly  1018 LPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRG 1082
                                                    |:..:..|:
Mouse   634 ----------------------------------------ALAARVRQV---------------- 642

  Fly  1083 SIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSR---N 1144
            |::.|.||..|..::..||.....|||.|||.||..|||.|..||::.:|...::....:.   :
Mouse   643 SVFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDSVALKSADIGIAMGQTGTDVSKEAANMILVD 707

  Fly  1145 PTISAVLKVIKEGRAAL--VTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISI 1207
            ...||::..::||:...  :.:|..|:...:.:.:..|::..:.::.|.|...|.|:|::.:...
Mouse   708 DDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIAALSLITLSTVCNLPSPLNAMQILWVNIIMDGP 772

  Fly  1208 FAFFFGKTESFDGMLVEQVPLS---SLISSTPLASLLLHLTVV---------------------- 1247
            .|...| .|..|...:.:.|.|   ::::...:..:|:...|:
Mouse   773 PAQSLG-VEPVDRDALRRPPRSVGDTILNRALILRVLMSAAVIIGGTLFIFWREIPANGTSTPRT 836

  Fly  1248 TAFQVTCWVHLHQQPWFKAFEPADEDHL----GCFENYTMFCISSFQYIILAFVFSKGAP-YRKP 1307
            |....||:|..   ..|.|.....:..|    |.|.|      ..|.|.:|..:..:.|. |..|
Mouse   837 TTMAFTCFVFF---DLFNALSCRSQTKLIFEIGFFRN------RMFLYSVLGSLLGQLAVIYAPP 892

  Fly  1308 L 1308
            |
Mouse   893 L 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	16/76 (21%)
		P-type_ATPase_cation	326..1281	CDD:319842	195/1034 (19%)
Atp2c2	NP_081198.1	Interaction with ORAI1. /evidence=ECO:0000250|UniProtKB:O75185	69..93		10/32 (31%)
		P-type_ATPase_SPCA	83..925	CDD:319779	203/1059 (19%)