DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp2b1

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001346435.1	Gene:	Atp2b1 / 67972	MGIID:	104653	Length:	1249	Species:	Mus musculus

Alignment Length:	1221	Identity:	242/1221 - (19%)
Similarity:	395/1221 - (32%)	Gaps:	430/1221 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYY---------------- 376
            |..|||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|
Mouse    81 REAVFGKN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVG 143

  Fly   377 ----------YYACVILLMSVFGITVSV------------LQTKKNQDVLQKTVYNTGNAWVVDH 419
                      .....|||..|..:.|:.            ||::..|:  ||        :.|..
Mouse   144 EEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQE--QK--------FTVIR 198

  Fly   420 KGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVPVTKTPLPSKRDMI 483
            .|...::|...|..|||.:: ..|..|..|.|||.||.: :|||.|||||..|.|:
Mouse   199 GGQVIQIPVADITVGDIAQV-KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS--------- 253

  Fly   484 FDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNIT--------AKGELIR----------- 529
            .||..    .|..||.|::    ||.:::...:...:.|        |.||...
Mouse   254 LDKDP----LLLSGTHVME----GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKN 310

  Fly   530 ------------------SILYPPPVDYK-----FEQDSYKF-------------IQFLAI-IAC 557
                              :.:...|:..:     .|:|..|.             :..||: |..
Mouse   311 KKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGK 375

  Fly   558 VGFIYTLVTKI------------------LRGTDP------VKIAVESLDLITIVVPPALPAAMT 598
            .|.:.:.:|.|                  |....|      ||..:..:.::.:.||..||.|:|
Mouse   376 AGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVT 440

  Fly   599 VGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKS 663
            :...|:.|::...........:....|:....|.|||||||         :.:.:..|..|..|.
Mouse   441 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT---------MNRMTVVQAYINEKH 496

  Fly   664 VDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQ 728
            ..::|....:                   |.::..:..||    .|.|...|.|  ||.|    :
Mouse   497 YKKVPEPEAI-------------------PPNILSYLVTG----ISVNCAYTSK--ILPP----E 532

  Fly   729 PRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNF--------DHGIVREFPFTSALQR 785
            ..|||    ....|:|.|......:.||         ::::        :..:.:.:.|.|..:.
Mouse   533 KEGGL----PRHVGNKTECALLGFLLDL---------KRDYQDVRNEIPEEALYKVYTFNSVRKS 584

  Fly   786 MSVVTRCLSDQVFNVYCKGSPEMLKKLC-------------KPQSLPDNYSQQLSEFAKKGYRII 837
            ||.|.: .||..|.::.||:.|::.|.|             :|:...|.....:...|.:|.|.|
Mouse   585 MSTVLK-NSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTI 648

  Fly   838 AIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDN 902
            .:||:  .......:.:..:..:|...:..:..|.:|:.::|:..:.|.....|.|...|:||||
Mouse   649 CLAFR--DFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDN 711

  Fly   903 ILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTS 967
            |.||.::|..|||:.|.:
Mouse   712 INTARAIATKCGILHPGE----------------------------------------------- 729

  Fly   968 RAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDT 1032
                               :|....||
Mouse   730 -------------------DFLCLEGK-------------------------------------- 737

  Fly  1033 WTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV 1097
                |....|::...|.  .||.|    .|.|..::               :.||.||..|..||
Mouse   738 ----DFNRRIRNEKGEI--EQERI----DKIWPKLR---------------VLARSSPTDKHTLV 777

  Fly  1098 -----IELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVI 1154
                 ..:......||:.|||.||..|||.|..|.::......:   ||.....:...::::|.:
Mouse   778 KGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAV 842

  Fly  1155 KEGRAALVTSFGIFKYMAAYSLVQFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGK 1214
            ..||....:   |.|::.....|..::|::.:     :.||.|...|.|:|:| ::...|.....
Mouse   843 MWGRNVYDS---ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTLASLALA 903

  Fly  1215 TESFDGMLVEQVPL---SSLISSTPLASLLLH--LTVVTAFQVTCWVHLHQQPWFKAFEPADED- 1273
            ||.....|:.:.|.   ..|||.|.:.::|.|  ..:|..|.:.          |...:..|.|
Mouse   904 TEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLL----------FAGEKFFDIDS 958

  Fly  1274 ------HLGCFENYTMFCISSFQYIILAFVFSKGAPYRK---------PLWSNWPLCL----AFI 1319
                  |....|:||:.    |...:|..:|:: ...||         .:::|...|.    .|:
Mouse   959 GRNAPLHAPPSEHYTIV----FNTFVLMQLFNE-INARKIHGERNVFEGIFNNAIFCTIVLGTFV 1018

  Fly  1320 VNLCIIVY-------LVLYPSDWVASFF---------QLI-VPPTMRFRYV 1353
            |.:.|:.:       ..|....|:.|.|         ||| ..||.|.:::
Mouse  1019 VQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFL 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	242/1221 (20%)
		E1-E2_ATPase	381..621	CDD:278548	69/332 (21%)
		Cation_ATPase	<758..813	CDD:289987	12/62 (19%)
		HAD_like	<1087..1137	CDD:304363	18/57 (32%)
Atp2b1	NP_001346435.1	ATPase-IIB_Ca	15..1064	CDD:273668	240/1214 (20%)
Atp2b1	NP_001346435.1	ATP_Ca_trans_C	1103..1178	CDD:372101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930