DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and Atp13a3

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_038944543.1	Gene:	Atp13a3 / 678704	RGDID:	1590881	Length:	1249	Species:	Rattus norvegicus

Alignment Length:	1346	Identity:	505/1346 - (37%)
Similarity:	740/1346 - (54%)	Gaps:	215/1346 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWAC--IFLTGGLLRLVLHW---WRHLYLYATCSQCSLEEA 212
            ::|..|||:|::.||  :|.|......|  :..|||.|.|:|:|   ||   :.|||.:.::::.
  Rat     8 IINKGQEDEMEIHGY--NLCRWKLAMVCVGVICTGGFLLLLLYWMPEWR---VKATCVRAAVKDC 67

  Fly   213 EQVLV--TEDYQGKHKMYHVKQIQVLT-----SSNLKTLLEKEQQSIERTHIECDHVENVLQLSV 270
            |.||:  |:::    :::...:|..|:     :.|.|:|:.|    :...|......||..:::.
  Rat    68 EVVLLRTTDEF----RIWFCAKIHFLSLENQPNLNAKSLVNK----VSNGHAVRLTEENRCEMNK 124

  Fly   271 HFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCS--YYHQQRGLPVHEQISRRI 333
            :..|    :...:|.|....:.|.||:..:.|..:.|||..:.|:  |.....||.......|::
  Rat   125 YSQS----QSQQMRYFTHHSIRYFWNDAIHNFDFLKGLDEGVSCASMYEKHSAGLTKGMHAYRKL 185

  Fly   334 VFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTK 398
            ::|.|||.|.:.....||..|||||||:|||||||||...:|||||..|::||:..|..|:...:
  Rat   186 LYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSIDEYYYYALAIVVMSIVSIISSLYSIR 250

  Fly   399 KNQDVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDE 461
            |...:|...|  ::|....|.......:|:.:..:||||::.||.:|..:.|||:||:|.||::|
  Rat   251 KQYVMLHDMVATHSTVRVSVCRVNEEIEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNE 315

  Fly   462 SMLTGESVPVTKTPLPSKR-------DMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTG 519
            |||||||||||||.||:..       :..:....|.||||||||.|||||:...:.|.|.|:.||
  Rat   316 SMLTGESVPVTKTNLPNPSVDVKGMGEEQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTG 380

  Fly   520 NITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDL 584
            ..|:||:|:||||||.|.|:|..:|:|.|:..|.::|.:|||||:|..||...:..:|.::|||:
  Rat   381 FSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVVVAGIGFIYTIVNSILNEKEVQEIIIKSLDI 445

  Fly   585 ITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVV 649
            |||.||||||||||.|..|||:|||...||||||:.||:.|.:|..||||||||||||||:||:.
  Rat   446 ITITVPPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQ 510

  Fly   650 PKSSTNQFQIPLKSV--DRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNI 712
            ...:| :|.:|..:|  :.|....|:..|.||||:|.:.|.:.||||||||||:.||.||::..
  Rat   511 RVENT-RFLLPEDNVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWVLEEATE- 573

  Fly   713 PDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREF 777
            .:|..:..:.||::| |...|...:.|....:.|:....::               ::.||||:|
  Rat   574 EETALHNRIMPTVVR-PSKQLLPESTTAGDQEMELFELPAI---------------YEIGIVRQF 622

  Fly   778 PFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFK 842
            ||:|||||||||.|.|.|:..:.|.||:||::..||||:::|.::.:.|.::.|:|:|:||:|.:
  Rat   623 PFSSALQRMSVVARTLGDKRMDAYMKGAPEVIASLCKPETVPVDFEKVLEDYTKQGFRVIALAHR 687

  Fly   843 ALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAI 907
            .|..|:.:.|||.:||:.:||||:|:|.:|::|:||.:|..|:..|:.|.|||:|:||||:|||:
  Rat   688 KLESKLTWHKVQHVSRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDNMLTAV 752

  Fly   908 SVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLF 972
            |||||||::.|...||...|.|..|....:.|                .|||..|
  Rat   753 SVARDCGMILPQDKVIIAEALPPKDGKVAKIN----------------WHYTDSL---------- 791

  Fly   973 KSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLP---TSDSLASVKTIDTWT 1034
            ..|..|:..|.|                                .:|   ..|||
  Rat   792 TQCSESSAIDSE--------------------------------AIPIKLAHDSL---------- 814

  Fly  1035 HNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIE 1099
             .|.::...|            |||:||::.::.::|.:.:..|:..|:::|||:||||..||..
  Rat   815 -EDLQVTRYH------------FAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLVEA 866

  Fly  1100 LQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTS 1164
            |||:||.|.|||||||||||||.||.||||||.|||:||||||:.|:||.|..:|:||||||:||
  Rat   867 LQNVDYFVGMCGDGANDCGALKRAHGGISLSEFEASVASPFTSKTPSISCVPNLIREGRAALMTS 931

  Fly  1165 FGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLS 1229
            |.:||:||.||::|:.||.:||||.|||.|.|:|::||.:|.:..|......::. .||.|.|.|
  Rat   932 FCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPAWK-ELVAQRPPS 995

  Fly  1230 SLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPAD---------------EDHL---- 1275
            .|||...|.|:|..:.:...||...:.      |.|.::..|               ..||
  Rat   996 GLISGALLFSVLSQIVISVGFQSLGFF------WVKQYKECDPYSEVCNTTRSACWNSSHLYNGT 1054

  Fly  1276 ---GC----FENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPS 1333
               .|    :||.|:|.||||||:.:|..||||.|:|:|.:.|:...::.|:....|::::|:|
  Rat  1055 ELDSCKIQNYENTTVFFISSFQYLTVAVAFSKGKPFRQPCYKNYFFVISVIILYVFILFIMLHP- 1118

  Fly  1334 DWVASFFQLI----VPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFK---------KYQVKR 1385
              |||..||:    ||  .::|..||.....:....|.||||.::.:::|         :|:...
  Rat  1119 --VASVDQLLEIMCVP--YQWRIYMLIIVLTNAFVSITVESFFLDTVLWKVVFSRDKQGEYRFST 1179

  Fly  1386 EK--------------NWV------TSKQKYMRLEHDISNIKNWPP 1411
            .:              :|.      |.|.|||.|..::.....|||
  Rat  1180 TQPPQESVDRWGKCCLSWALSCRKKTPKAKYMYLAQELQFDPEWPP 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	37/144 (26%)
		P-ATPase-V	173..1355	CDD:273738	478/1239 (39%)
		E1-E2_ATPase	381..621	CDD:278548	117/248 (47%)
		Cation_ATPase	<758..813	CDD:289987	24/54 (44%)
		HAD_like	<1087..1137	CDD:304363	38/49 (78%)
Atp13a3	XP_038944543.1	P-ATPase-V	14..1142	CDD:273738	486/1255 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11666
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.800