DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp1a1a.3

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_571763.1	Gene:	atp1a1a.3 / 64614	ZFINID:	ZDB-GENE-001212-3	Length:	1024	Species:	Danio rerio

Alignment Length:	1205	Identity:	245/1205 - (20%)
Similarity:	395/1205 - (32%)	Gaps:	418/1205 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 GLDLNIPCSYYHQQRGLPV---HEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVI 368
            |.|||         :||.:   .|.::|.   |.|.:|.|:...:.:.|...|     |..|..:
Zfish    57 GTDLN---------KGLSITRAKEILARD---GPNALTPPVTTPEWVKFCRQL-----FGGFQTL 104

  Fly   369 LW-------FTY------------DYYYYACVILLMSVFGITV----SVLQTKKNQDVL------ 404
            ||       |.|            |..|...|:    .|.:||    |..|..|:..::
Zfish   105 LWIGALLCFFAYSIQAASEEEPANDNLYLGLVL----AFVVTVNGCFSYYQEAKSSRIMDSFRNL 165

  Fly   405 --QKT-VYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISG-NCILDESMLT 465
              ||. |...|...|:|         ...:|.||::|: ..|..:..|..::|. .|.:|.|.||
Zfish   166 VPQKALVVREGEKSVID---------AEDVVVGDLVEV-KGGDRIPADIRIVSSQGCKVDNSSLT 220

  Fly   466 GESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGEL--I 528
            |||.|.|:.|     :|..|.....|:..|..|..:.    |:.:  ..|:|||:.|..|.:  :
Zfish   221 GESEPQTRAP-----EMSSDNPLETRNIAFFSTNCVD----GAAR--GVVVNTGDRTVMGRIASL 274

  Fly   529 RSILY--PPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPP 591
            .|.|.  ..|:..:.|.    ||..:..:|....:..||..::.|.:.::..:..:.:|...||.
Zfish   275 ASSLEGGQTPIAREIEH----FIHIITGVAVFLGLTFLVLSLILGYNWLEGVIFLIGIIVANVPE 335

  Fly   592 ALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGL---DMWGVVPKSS 653
            .|||.:||......||:........:..::...||....|.|||||||::.:   .||
Zfish   336 GLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQNRMTVAHMW------- 393

  Fly   654 TNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKY 718
                           ||:.:....|..:.|       |...|.   .|..|...       ....
Zfish   394 ---------------FDNHIHIADTTENQT-------GASFDR---SSATWSAL-------ARVA 426

  Fly   719 GILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSAL 783
            |:....:.:..:..:..:....:|..:|......::  |:...::..::|:..  :.|.||.|..
Zfish   427 GLCNRAVFQSNQSHIPVLKRDTAGDASESALLKCIE--LSCGSVAEMRENYTK--LAEIPFNSTN 487

  Fly   784 Q-RMSVVTRCLSDQVFN-VYCKGSPEMLKKLC-------KPQSLPDN----YSQQLSEFAKKGYR 835
            : ::|:.....|.:..: :..||:||.:.:.|       |.|.:.|.    :.....|....|.|
Zfish   488 KYQVSIHKNPNSSEPKHLLVMKGAPERILERCSTIFIQGKEQPMDDEMKDAFQNAYLELGGLGER 552

  Fly   836 IIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINAL---NAAKIRTIM 897
            ::......|... .:.:......||:....|.|.||.|.:.:.|....|.:|:   .:|.|:.||
Zfish   553 VLGFCHFCLPDD-QFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIM 616

  Fly   898 ITGDNILTAISVARDCGIVSPSQSVI-------TVHADPIGDSANIQTNTGTECNFDNSSDKHYK 955
            :|||:.:||.::|:..||:|.....:       .:|.|.:                 |..|.
Zfish   617 VTGDHPITAKAIAKGVGIISEGNETVDDIAARLKIHIDEV-----------------NPRDA--- 661

  Fly   956 LHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPT 1020
                             |:|                    :.|
Zfish   662 -----------------KAC--------------------VIH---------------------- 667

  Fly  1021 SDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIY 1085
                            ..||  |:..||.                 :.|......||      ::
Zfish   668 ----------------GGEL--KNMTDEQ-----------------LDDVLQHHTEI------VF 691

  Fly  1086 ARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTI 1147
            ||.||.||..:|...|.....||:.|||.||..|||.|..|:::....:.:   |:.....:...
Zfish   692 ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNF 756

  Fly  1148 SAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVM------ILYSIDSNLTDKQYLYVDLGLIS 1206
            ::::..::|||..    |...|...||:|...|..|      :|..|...|.....|.:|||
Zfish   757 ASIVTGVEEGRLI----FDNLKKSIAYTLTSKIPEMSPFLMFVLVGIPLPLGTVTILCIDLG--- 814

  Fly  1207 IFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLL--------------HLTVVTAFQV----- 1252
                            .:.||..||...|..:.::.              .|..|:..|:
Zfish   815 ----------------TDMVPAISLAYETAESDIMKRQPRNAATDRLVNERLISVSYGQIGMIQA 863

  Fly  1253 -----TCWVHLHQQPWFKAFEPAD----------------EDHLG---CFEN-----YTMFCISS 1288
                 |.:|.|.:    ..|.|.|                ||..|   .:|:     ||  |.::
Zfish   864 VGGFFTYFVILAE----NGFLPYDLVGIRVGWEDRFLNDLEDSYGQQWTYESRKIVEYT--CHTA 922

  Fly  1289 F--QYIILAF------------VFSKGAPYR-------------------------------KPL 1308
            |  ..:|:.:            :|.:|...|                               |||
Zfish   923 FFASIVIVQWTDLLICKTRRLSIFQQGMKNRVLTFGLLEETALAAFLSYCPGMEVAVRMYPLKPL 987

  Fly  1309 WSNWPLCLAFIVNLCIIVY-------LVLYPSDWV 1336
            |  | .| ||..:|.|.:|       |...|..||
Zfish   988 W--W-FC-AFPYSLLIFIYDEVRKYILRRNPGGWV 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	245/1205 (20%)
		E1-E2_ATPase	381..621	CDD:278548	63/257 (25%)
		Cation_ATPase	<758..813	CDD:289987	11/56 (20%)
		HAD_like	<1087..1137	CDD:304363	19/52 (37%)
atp1a1a.3	NP_571763.1	ATPase-IIC_X-K	32..1024	CDD:273445	245/1205 (20%)
		Cation_ATPase_N	41..115	CDD:214842	18/74 (24%)
		E1-E2_ATPase	135..366	CDD:278548	63/259 (24%)
		Cation_ATPase	428..522	CDD:289987	15/97 (15%)
		COG4087	604..753	CDD:226572	49/268 (18%)
		Cation_ATPase_C	800..1009	CDD:279079	42/237 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910