Protein Alignment anne and atp1a3a

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_571759.2
• Gene: atp1a3a / 64610
• ZFINID: ZDB-GENE-001212-7
• Length: 1023
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 235/1159 - (20%)
• Similarity: 378/1159 - (32%)
• Gaps: 375/1159 - (32%)

  Fly   336 GDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILW-------FTY------------DYYYYACV 381
            |.|.:|.|....:.:.|...|     |..||::||       ..|            |..|...|
Zfish    76 GPNALTPPPTTPEWVKFCRQL-----FGGFSILLWIGAILCFLAYAIQAATEDEPAGDNLYLGIV 135

  Fly   382 ILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTL 446
            :..:.:.....|..|..|:..:::..........:|..:|...::....:|.||::|: ..|..:
Zfish   136 LSAVVIITGCFSYFQEAKSSKIMESFKNMVPQQALVIREGEKLQINAEEVVGGDLVEV-KGGDRI 199

  Fly   447 HCDAILISGN-CILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKK 510
            ..|..:||.: |.:|.|.|||||.|.|::|     |...|.....|:..|..|..::    |:.:
Zfish   200 PADLRIISAHGCKVDNSSLTGESEPQTRSP-----DCTHDNPLETRNIAFFSTNCVE----GTAR 255

  Fly   511 VLAFVINTGNITAKGEL--IRSILY--PPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRG 571
              ..|:.||:.|..|.:  :.|.|.  ..|:..:.|.    ||..:..:|....:...:..|:.|
Zfish   256 --GIVVCTGDRTVMGRIATLTSGLETGKTPIAKEIEH----FIHIITGVAVFLGVTFFILSIILG 314

  Fly   572 TDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTG 636
            ...::..:..:.:|...||..|.|.:||......||:........:..::...||.:..|.||||
Zfish   315 YSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 379

  Fly   637 TLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFES 701
            |||:                        :|:...|..|                    |.::.|:
Zfish   380 TLTQ------------------------NRMTVAHMWF--------------------DNQIHEA 400

  Fly   702 TGWELEDSNNIPDTEKYGILYPTILRQPR-GGLSGMAETESGS------KNEIKRQSSVDDLLAT 759
            .  ..||.:.....:..|    |.|...| ..|...|..::|.      |.::...:|...||..
Zfish   401 D--TTEDQSGASFDKSSG----TWLALARVAALCNRAVFKAGQESLPILKRDVAGDASESALLKC 459

  Fly   760 VGIS------PSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVY---CKGSPEMLKKLCKP 815
            :.:|      ...||..   |.|.||.|. .:..:....|.:...|.|   .||:||.:...|.
Zfish   460 IELSCGSVKAMRDKNKK---VAEIPFNST-NKYQLSVHELDESEENHYLLVMKGAPERILDRCS- 519

  Fly   816 QSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKM-----------NYTKVQRLSREEVENNMEFLG 869
            ..|.....|.:.|..|:.::...:....|..::           .|.|......:::....:.|.
Zfish   520 TILQQGKEQPMDEELKEAFQNAYLELGGLGERVLGFCHLVMPGDKYPKGFAFDTDDINFQTDNLC 584

  Fly   870 FVILENRLKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIG 931
            ||.|.:.:.|....|.:|:   .:|.|:.||:|||:.:||.::|:..||:|...
Zfish   585 FVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGN----------- 638

  Fly   932 DSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTI 996
                                                                ||.|..|
Zfish   639 ----------------------------------------------------ETVEDIA------ 645

  Fly   997 FHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDG 1061
                             |...:|.|..          ...||:..:.|..|
Zfish   646 -----------------ARLNIPVSQV----------NPRDAKACVIHGTD-------------- 669

  Fly  1062 KTWQIVKDYFPEEMEILLTRGS--IYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAH 1124
                 :||...::|:.:|...:  ::||.||.||..:|...|.....||:.|||.||..|||.|.
Zfish   670 -----LKDLSQDQMDEVLKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 729

  Fly  1125 AGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFIS----- 1181
            .|:::..:.:.:   |:.....:...::::..::|||..    |...|...||:|...|.
Zfish   730 IGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIPEITPF 790

  Fly  1182 -VMILYSIDSNLTDKQYLYVDLG-----------------------------------LISIFAF 1210
             ..||.:|...|.....|.:|||                                   ||||...
Zfish   791 LFFILVNIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPLRDKLVNERLISIAYG 855

  Fly  1211 FFGKTESFDG------MLVEQVPLSSLI----------SSTPLAS-----------LLLHLTVVT 1248
            ..|..::..|      :|.|...|.|::          |:..|..           .::..|..|
Zfish   856 QIGMIQALGGFFSYFVILAENGFLPSVLVGIRLNWDDRSNNDLEDSYGQQWTYEQRKIVEFTCHT 920

  Fly  1249 AFQVTC----WV----------HLHQQPW------FKAFEPADEDHLGCFENYTMFC----ISSF 1289
            ||.|:.    |.          .:.||..      |..||   |..|..|.:|   |    ::..
Zfish   921 AFFVSIVVVQWADVIICKTRRNSVFQQGMKNKILIFGLFE---ETALAAFLSY---CPGMDVALR 979

  Fly  1290 QYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVY-----LVL--YPSDWV 1336
            .|               ||..:|..| ||..:..|.||     |:|  .|..||
Zfish   980 MY---------------PLKPSWWFC-AFPYSFLIFVYDEIRKLILRRNPGGWV 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	218/1091 (20%)
atp1a3a	NP_571759.2	ATPase-IIC_X-K	30..1023	CDD:273445	235/1159 (20%)