DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp1a2a

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_571758.1	Gene:	atp1a2a / 64609	ZFINID:	ZDB-GENE-001212-6	Length:	1017	Species:	Danio rerio

Alignment Length:	979	Identity:	196/979 - (20%)
Similarity:	329/979 - (33%)	Gaps:	274/979 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 GLDLNIPCSYYHQQRGLPVHEQISRRIV-FGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILW 370
            |:||         .||| .|::....:. .|.|.:|.|....:.:.|.:.|     |..||::||
Zfish    51 GVDL---------ARGL-THKRAMEILARDGPNALTPPPTTPEWVKFCKQL-----FGGFSILLW 100

  Fly   371 F-------------------TYDYYYYACVILLMSVFGITVSVLQTKKNQDVLQKTVYNTGNAWV 416
            .                   ..|..|...|:..:.:.....|..|..|:..::...........:
Zfish   101 IGAILCFLAYSIQAATEDEPVNDNLYLGVVLSAVVIITGCFSYYQEAKSSRIMDSFKNMVPQQAL 165

  Fly   417 VDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCD-AILISGNCILDESMLTGESVPVTKTPLPSKR 480
            |...|...::....:|.||::|| ..|..:..| .|:.|..|.:|.|.|||||.|.|::|
Zfish   166 VIRDGEKLQINAEEVVQGDLVEI-KGGDRVPADLRIISSSGCKVDNSSLTGESEPQTRSP----- 224

  Fly   481 DMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKGEL--IRSILY--PPPVDYKF 541
            :...:.....|:..|..|..::....|      .||.||:.|..|.:  :.|.|.  ..|::.:.
Zfish   225 EFTHENPLETRNISFFSTNCVEGTAHG------IVIATGDHTVMGRIATLASGLEVGQTPINMEI 283

  Fly   542 EQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIVVPPALPAAMTVGRFYAQK 606
            |.    ||..:..:|....:...:..|:.|...::..:..:.:|...||..|.|.:||......|
Zfish   284 EH----FIHIITGVAIFLGMSFFILSIILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAK 344

  Fly   607 RLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGL---DMWGVVPKSSTNQFQIPLKSVDRLP 668
            |:........:..::...||.:..|.|||||||::.:   .||
Zfish   345 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW---------------------- 387

  Fly   669 FDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTEKYGILYPTILRQPR-GG 732
            ||:.:....|..                   :.:|.:.:.|:            ||.....| ||
Zfish   388 FDNQIHEADTTE-------------------DQSGCDFDKSS------------PTWFSLSRVGG 421

  Fly   733 LSGMAETESGSKN-EIKRQSSVDD-----LLATVGISPSQKNFDHG---IVREFPFTSALQRMSV 788
            |...|..::|.:. .|:.:.:..|     ||..|.|.........|   .|.|.||.|. .:..:
Zfish   422 LCNRAVFKAGQEEIPIRTRDTAGDASESALLKCVEILSGNVETLRGNNRKVAEIPFNST-NKYQL 485

  Fly   789 VTRCLSDQVFN--VYCKGSPEMLKKLCK-----------PQSLPDNYSQQLSEFAKKGYRIIAIA 840
            ....|.|....  :..||:||.:...|.           .....|.:.....|....|.|::...
Zfish   486 SIHELEDSPTGHLLVMKGAPERILDRCSTIMINGVEFPIDDDWMDAFQGAYMELGGLGERVLGFC 550

  Fly   841 FKALSHKMNYTKVQRLSREEVE---NNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDN 902
            ...|| ...:.:......::|.   |.:.|||.:.:.:..:......:....:|.|:.||:|||:
Zfish   551 HLFLS-PSQFPRGFEFDCDDVNFPVNQLCFLGLISMVDPPRAAVPDAVGKCRSAGIKVIMVTGDH 614

  Fly   903 ILTAISVARDCGIVSPSQSVITVHADPIGDSANI---QTNTGTECNFDNSSDKHYKLHYTLDLGS 964
            .:||.::|:..||:|.....:    :.|.:..||   |.|....
Zfish   615 PITAKAIAKGVGIISEGNETV----EDIAERLNIPLSQVNPREA--------------------- 654

  Fly   965 KTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKT 1029
                    |:|                    :.|    .|.:.:.:|.|
Zfish   655 --------KAC--------------------VVH----GSDLKDMSSEY---------------- 671

  Fly  1030 IDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQ 1094
            :|....|..|:                                           ::||.||.||.
Zfish   672 LDDILRNHTEI-------------------------------------------VFARTSPQQKL 693

  Fly  1095 ALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKE 1156
            .:|...|.....||:.|||.||..|||.|..|:::..|.:.:   |:.....:...::::..::|
Zfish   694 IIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGITGSDVSKQAADMILLDDNFASIVTGVEE 758

  Fly  1157 GRAALVTSFGIFKYMAAYSLVQFIS------VMILYSIDSNLTDKQYLYVDLG--LISIFAFFFG 1213
            ||..    |...|...||:|...|.      :.|:.|:...|.....|.:|||  ::...:..:.
Zfish   759 GRLI----FDNLKKSIAYTLTSNIPEITPFLLFIIASVPLPLGTVTILCIDLGTDMVPAISLAYE 819

  Fly  1214 KTES 1217
            ..||
Zfish   820 SAES 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	196/979 (20%)
		E1-E2_ATPase	381..621	CDD:278548	54/244 (22%)
		Cation_ATPase	<758..813	CDD:289987	14/59 (24%)
		HAD_like	<1087..1137	CDD:304363	20/52 (38%)
atp1a2a	NP_571758.1	ATPase-IIC_X-K	34..1017	CDD:273445	196/979 (20%)
		Cation_ATPase_N	35..109	CDD:214842	18/72 (25%)
		E1-E2_ATPase	129..360	CDD:278548	54/246 (22%)
		Cation_ATPase	422..515	CDD:289987	22/93 (24%)
		COG4087	600..746	CDD:226572	49/261 (19%)
		Cation_ATPase_C	793..1002	CDD:279079	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930