Protein Alignment anne and atp2a1

DIOPT Version :10

• Sequence 1: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_012810385.1
• Gene: atp2a1 / 613090
• XenbaseID: XB-GENE-975115
• Length: 996
• Species: Xenopus tropicalis
• Alignment Length: 1218
• Identity: 261/1218 - (21%)
• Similarity: 422/1218 - (34%)
• Gaps: 383/1218 - (31%)

  Fly   322 GLPVHEQISRRIV------FGDNEITVPLRDFKTL--LFLEVLNPFYVFQLF------SVILWF- 371
            |:..:..:|..||      ||.||:  |..:.|::  |..|......|..|.      .|:.||
 Frog    17 GVNENTGLSPEIVKKNFDKFGPNEL--PAEEGKSIWELVAEQFEDLLVRILLLAACISFVLAWFE 79

  Fly   372 ----TYDYYYYACVILLMSVFGITVSVLQTKKNQD---VLQKTVYNTGNAWVVDHKGLSKELPTR 429
                |...:....||||:.:....|.|.|.:..:|   .|::.....|..:..|.|.:.: :..|
 Frog    80 EGEETVTAFVEPFVILLILIANAVVGVWQERNAEDAIEALKEYEPEMGKVYRSDRKSVQR-IKAR 143

  Fly   430 AIVPGDIIEIPSSGCTLHCDAILI---SGNCILDESMLTGESVPVTK--TPLPSKRDMIFDKTEH 489
            .||||||:|: :.|..:..|..||   |....:|:|:||||||.|.|  ..:|..|.:..||
 Frog   144 EIVPGDIVEV-AVGDKVPADIRLISIKSTTLRIDQSILTGESVSVIKHTEAVPDPRAVNQDK--- 204

  Fly   490 ARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITAKG----ELIRSILYPPPVDYKFEQDSYKFIQ 550
             ::.||.||.|      |:.|.:..||.||..|..|    |:..:.....|:..|.::...:..:
 Frog   205 -KNMLFSGTNV------GAGKAIGVVIATGPNTEIGKIRDEMAATEQEKTPLQQKLDEFGEQLSK 262

  Fly   551 FLAIIACVGFIYTLVTKILRGTDPV-------------KIAVESLDLITIVVPPALPAAMTVGRF 602
            .:::| ||.   ..:..|....||:             ||||.   |....:|..|||.:|....
 Frog   263 VISLI-CVA---VWLINIGHFNDPIHGGSWIKGAIYYFKIAVA---LAVAAIPEGLPAVITTCLA 320

  Fly   603 YAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDM--WGVVPK-----SSTNQFQIP 660
            ...:|:........|..|:...|..:..|.|||||||.:.:.:  ..|:.|     .|.|:|.|.
 Frog   321 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVLDKVDGDICSLNEFSIT 385

  Fly   661 -------------LKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLK-MFESTGWELEDSNN 711
                         .|||....:|    |:|...:|..|......|..:.| :||..| |..::..
 Frog   386 GSTYAPEGEVLKNDKSVKAGQYD----GLVELATICALCNDSSLDYNESKGVFEKVG-EATETAL 445

  Fly   712 IPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVRE 776
            ....||..:.                .||..|.::::|.::.:.::..:            :.:|
 Frog   446 TTLVEKMNVF----------------NTEVRSLSKVERANACNSVIKQL------------MKKE 482

  Fly   777 FPFTSALQRMSVVTRCLSDQVF------NVYCKGSPEMLKKLCK-----------PQSLPDNYSQ 824
            |....:..|.|:...|...:..      .::.||:||.:...|.           ..::.|....
 Frog   483 FTLEFSRDRKSMSVYCTPAKASRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTPAIKDKILT 547

  Fly   825 QLSEF--AKKGYRIIAIAFKALSHKMNYTKVQRLSREEV-----------ENNMEFLGFVILENR 876
            .:.|:  .:...|.:|:|.:....|          |||:           |.::.|:|.|   ..
 Frog   548 VIKEWGTGRDTLRCLALATRDTPPK----------REEMVLDDATKFVDYETDLTFVGCV---GM 599

  Fly   877 LKPDTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQT 938
            |.|...:|:.::   ..|.||.|||||||..|||::.|..||......|
 Frog   600 LDPPRKEVMGSIKLCREAGIRVIMITGDNKGTAIAICRRIGIFGEDDDV---------------- 648

  Fly   939 NTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTN 1003
               :.|.|                   |.|.:
 Frog   649 ---SRCAF-------------------TGREF--------------------------------- 658

  Fly  1004 SLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVK 1068
                        ..||.::                            :|:.|
 Frog   659 ------------DDLPPTE----------------------------QREAC------------- 670

  Fly  1069 DYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSE-- 1131
                       .|.|.:||:.|..|..:|..||:.|...||.|||.||..|||.|..||::..
 Frog   671 -----------KRASCFARVEPTHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGT 724

  Fly  1132 TEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMI--LYSIDSNLTD 1194
            ..|..||.....:...|.::..::||||.........:|:.:.::.:.:.:.:  ...:...|..
 Frog   725 AVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIP 789

  Fly  1195 KQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLL---------HLTVVTAF 1250
            .|.|:|:|....:.|...|.... |..::::.|.|   ...||.|..|         ::...|..
 Frog   790 VQLLWVNLVTDGLPATALGFNPP-DLDIMDRPPRS---PKEPLISGWLFFRYLAIGGYVGAATVG 850

  Fly  1251 QVTCW---------VHLHQQPWFK--AFEPADEDHLGC--FEN---YTM---------FC----- 1285
            ....|         |..:|...|.  ..|.||.:.|.|  ||:   .||         .|
 Frog   851 AAAWWFMYADDGPEVTFYQLSHFMQCTEENADFEGLECEIFESPVPMTMALSVLVTIEMCNALNS 915

  Fly  1286 ISSFQYIILAFVFSKGAPYRKPLWSN-W---PLCLAFIVNLCIIVYLVLYPSDWVASFFQLIVPP 1346
            :|..|.::           |.|.|.| |   .:||:..::     :|:||           :.|.
 Frog   916 LSENQSLV-----------RMPPWVNIWLLGSICLSMSLH-----FLILY-----------VEPL 953

  Fly  1347 TMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNWVTSKQ 1394
            .|.|:...|.:.....:..|.:...|::.|:  |:..   :|::..|:
 Frog   954 PMIFKLTPLNFTQWFVVLKISIPVILLDELL--KFVA---RNYLEEKK 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	235/1081 (22%)
atp2a1	XP_012810385.1	P-type_ATPase_SERCA	5..989	CDD:319778	259/1209 (21%)