DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and JYalpha

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster

Alignment Length:	1235	Identity:	240/1235 - (19%)
Similarity:	424/1235 - (34%)	Gaps:	370/1235 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 NRFQRINGLDLNIPCSYYHQ-----QRGLPVHEQISR----------------RI-VFGDNEITV 342
            |:..:|||.:.......:.:     ...:||.|.:.|                |: :.|.|.:|.
  Fly     7 NKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTP 71

  Fly   343 PLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMS---------VFGITVSVL--- 395
            .....|.::||:.:     |..|:::||......:...:|.|.:         ..||.::||
  Fly    72 QPPTPKWIVFLKTM-----FGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIV 131

  Fly   396 -------QTKKNQDVLQKTVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILI 453
                   |..|:..::............|..:|....:.:..||.|||:|: ..|..:..|..::
  Fly   132 TGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEV-KFGDRVPADIRIL 195

  Fly   454 SGNCI-LDESMLTGESVPVTKT-------PLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKK 510
            ..:.: :|.|.|||||.|..::       ||.:|            :..|..|.|::....|
  Fly   196 EAHGLKVDNSSLTGESEPQVRSTEFTHENPLETK------------NLAFFSTNVLEGTCRG--- 245

  Fly   511 VLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPV 575
               .||.||:.|..|.:.........|.....::...||:|:.|.|.:..:......:..|.:.:
  Fly   246 ---VVIATGDSTVMGRIANLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFI 307

  Fly   576 KIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTE 640
            ...|..:.:|...||..|...:||......||:.:......:..::...||.:..|.|||||||:
  Fly   308 DAVVFLIGIIVANVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQ 372

  Fly   641 DGL---DMWG---VVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMF 699
            :.:   .:|.   :|...:|..|:.....::...|:........|:|.....|:.     |:.:|
  Fly   373 NRMTVAHLWYDQIIVESDTTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQD-----DIPVF 432

  Fly   700 ESTGWELEDSNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISP 764
            :      :|.|                               |:.:|.......:.:.|.:| :.
  Fly   433 K------KDVN-------------------------------GNASEAALLKFTETIFAGIG-AF 459

  Fly   765 SQKNFDHGIVREFPFTSALQ-RMSVVTRCLSDQVFNVYCKGSPEMLKKLCK-----------PQS 817
            .||   |..:.|.||.|..: ::||.....||..|.|..||:||.:...|.           ..:
  Fly   460 RQK---HIKLTEIPFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPT 521

  Fly   818 LPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVE---NNMEFLGFVILENRLKP 879
            |...:.:...|....|.|::..| ..|.....|......|.:...   .|:.|||.:.|   :.|
  Fly   522 LKLEFEEAYLEMGGMGERVLGFA-DLLLPMSKYPISYEFSADPPNFPLENLRFLGLISL---IDP 582

  Fly   880 DTTKVINAL---NAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTG 941
            ....|.:|:   .:|.:|.||:|||:.:||.::||..||::
  Fly   583 PRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT------------------------ 623

  Fly   942 TECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLV 1006
                                                    .|...:...|.|.|:..::|
  Fly   624 ----------------------------------------TPTAEDIAKQRGVTVLDIDS----- 643

  Fly  1007 NESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYF 1071
            .::|:.....|     .|..:|..:.    ||.:                             |:
  Fly   644 RQATAIVVHGG-----ELREMKAEEL----DAVI-----------------------------YY 670

  Fly  1072 PEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASI 1136
            ..|:        ::||.||.||..:|...|.....||:.|||.||..|||.|..|:::..:.:.:
  Fly   671 HNEI--------VFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDV 727

  Fly  1137 ---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSL-------VQFISVMILYSIDSN 1191
               |:.....:...::::..|:|||..    |...|...||:|       |.|: ..:::.|...
  Fly   728 SKQAADMILLDDNFASIVVGIEEGRII----FDNLKKSIAYTLTSNLPEIVPFL-FFVIFDIPLA 787

  Fly  1192 LTDKQYLYVDLG--LISIFAFFFGKTES----------FDGMLVEQVPLSSLISSTPLASLLLHL 1244
            |.....|.:|:|  ::...:..:.|.||          |:..||.:    .||       |:.:|
  Fly   788 LGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNK----KLI-------LMAYL 841

  Fly  1245 TVVTAFQVTCWVHLHQQPWFKAFEPAD----------------EDHLGCFENY-----------T 1282
            .:.....|.|:...........|.|:.                ||..|....|           |
  Fly   842 QIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGT 906

  Fly  1283 MFCISSFQYIILAFVFS-------KGAPYRKPLWS---NWPLCLAFIVNLCIIVYLVLYPSDWVA 1337
            .|.:|    |::..||.       :.:..::.:.:   |:.|.|.||: .|::.|:.::..
  Fly   907 GFFVS----IVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFII-ACLLCYVPVFEK---- 962

  Fly  1338 SFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVF-----KKYQVKREK-NWVTSKQKY 1396
                     |:|...:       .||..|:  :|....|:|     :::.::|.. .||..:..|
  Fly   963 ---------TLRMYSI-------KFIWWIY--AFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009

Fly 1397 1396
Fly 1010 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	230/1186 (19%)
		E1-E2_ATPase	381..621	CDD:278548	55/266 (21%)
		Cation_ATPase	<758..813	CDD:289987	19/55 (35%)
		HAD_like	<1087..1137	CDD:304363	19/52 (37%)
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	235/1223 (19%)
		Cation_ATPase_N	29..102	CDD:214842	15/77 (19%)
		E1-E2_ATPase	123..354	CDD:278548	52/249 (21%)
		Cation_ATPase	416..509	CDD:289987	29/138 (21%)
		COG4087	<673..738	CDD:226572	22/72 (31%)
		Cation_ATPase_C	785..994	CDD:279079	43/246 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840