DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment anne and atp13a3

DIOPT Version :9

Sequence 1:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_009304446.2	Gene:	atp13a3 / 572029	ZFINID:	ZDB-GENE-120521-1	Length:	1225	Species:	Danio rerio

Alignment Length:	1345	Identity:	518/1345 - (38%)
Similarity:	743/1345 - (55%)	Gaps:	198/1345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 KPCIGLLNPDQEDQMKVCGYRRSLMRTGFCWACI--FLTGGLLRLVLHWWRHLYLYATCSQCSLE 210
            |..:.::|...||:|::.|:|  |.|......|.  |.|||.|.|:|:|.....:.|||::.::.
Zfish     3 KEDLKVVNRGLEDEMELRGFR--LCRWKLVLVCCGGFCTGGFLFLLLYWMPEWCVKATCTRTTVR 65

  Fly   211 EAEQVLV--TEDYQGKHKMYHVK-QIQVLTSSNLKTLLEKE---QQSIERTHIECDHVENVLQLS 269
            :||..|:  |::::   :.:..| :|.:....|....|..:   .|:.:..|...|...|.:..|
Zfish    66 DAEVALLRSTDEFK---RWFRAKVRIMLAPGKNPYDTLNSQTASPQANDHAHNMTDSTHNKISRS 127

  Fly   270 VHFTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGL-DLNIPCSYYHQQR--GLPVHEQISR 331
            |.....|      ||.|......|.||:....|:.:.|| ||||.||..|.:.  ||..::|..|
Zfish   128 VESQQVQ------IRYFTLHSTKYFWNDTIQNFEVLKGLEDLNISCSSVHSKHSAGLNKNQQEYR 186

  Fly   332 RIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQ 396
            |..||.|||.|.:.....||..|||||||:||||||:||.|.:|||||..|::||...|..|:..
Zfish   187 RFFFGLNEIDVKVPSLFKLLIKEVLNPFYIFQLFSVVLWCTDEYYYYAMAIVVMSFISIATSLYT 251

  Fly   397 TKKNQDVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCIL 459
            .||...:|...|  ::|....|...:..::|..:..:||||:|.|||:|..:.|||:||.|.||:
Zfish   252 IKKQYVMLHDMVATHSTVRVTVCRGESETEEALSTDLVPGDVIVIPSNGTIMPCDAVLICGTCIV 316

  Fly   460 DESMLTGESVPVTKTPLP--------SKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVI 516
            :||||||||||||||.||        |..|.|:...||.||||||||.||||||...:.|.|.|:
Zfish   317 NESMLTGESVPVTKTDLPNPERDKKGSDGDQIYSTEEHKRHTLFCGTNVIQTRYYTGEMVKAVVV 381

  Fly   517 NTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVK-IAVE 580
            .||..||||:||||||||.|.|:|..:|:|.|:..|..:|.|.|||:||.||| ..:||| |.|:
Zfish   382 RTGFSTAKGQLIRSILYPKPTDFKLYRDAYLFLLCLVAVASVVFIYSLVMKIL-NQEPVKEIIVK 445

  Fly   581 SLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDM 645
            |||:|||.||||||||||.|..|||:||:...||.|||:.||:.|.:|..|||||||||||||||
Zfish   446 SLDIITITVPPALPAAMTAGIVYAQRRLRKVGIFSISPQRINICGQLNLVCFDKTGTLTEDGLDM 510

  Fly   646 WGVVPKSSTNQFQIPLKSVD--RLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELED 708
            || :.:...::||...:..|  .|....|:..|.||||:|.:.|::.||||||||||:|||.|.:
Zfish   511 WG-IQRVEDSRFQHSEERADDKSLVTSRFVSCMATCHSLTKIEGQLSGDPLDLKMFEATGWILVE 574

  Fly   709 SNNIPDTEKYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQ------- 766
            :     ||:                    ||....:.|:......:.||....|||.|
Zfish   575 A-----TEE--------------------ETAHHDRIELTYVKPPNQLLPPPVISPEQDMELSEL 614

  Fly   767 ----KNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLS 827
                .::..||||:|.|:|||||||||.|.:.::..:.|.||:||::..|||.:|:|:::::.|.
Zfish   615 YELSASYMIGIVRQFSFSSALQRMSVVVRQIGERRMDAYLKGAPEVVASLCKKESVPEDFAEVLE 679

  Fly   828 EFAKKGYRIIAIAFKALSHKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAK 892
            ::.|:|:|:||:|.:.|..|:.:.|||.::|:::|.||:|||.::::|:||.:|..|::.|..|.
Zfish   680 DYTKQGFRVIALAHRRLESKLTFHKVQNINRDQIEKNMDFLGLIVMQNKLKTETPGVLDDLRRAN 744

  Fly   893 IRTIMITGDNILTAISVARDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLH 957
            |||:|:||||:|||||||||||::.|...||...|.|..|....:.|                .|
Zfish   745 IRTVMVTGDNMLTAISVARDCGMIQPLDLVIIADAVPPKDGQAAKIN----------------WH 793

  Fly   958 YTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSD 1022
            |. |..||                                                 .|..||
Zfish   794 YA-DKPSK-------------------------------------------------HSNKPT-- 806

  Fly  1023 SLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYAR 1087
            .|..|:.|         |...|:.|||..:::..|||.||::.::.::|.:.::.|:..|:::||
Zfish   807 KLEEVEII---------LEDGHSVDESRSQEQYHFAMSGKSFAVIIEHFQDLLQKLVLHGTVFAR 862

  Fly  1088 MSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLK 1152
            |:||||..||..|:::||.|.|||||||||||||.|||||||||.|||:||||||..|:|:.|..
Zfish   863 MAPDQKTQLVETLESVDYFVGMCGDGANDCGALKRAHAGISLSELEASVASPFTSTTPSITCVPN 927

  Fly  1153 VIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTES 1217
            :|:||||||:|||.:||:||.||::|.:||.:||||.|||.|.|:|::|:.:|.:..|......:
Zfish   928 LIREGRAALITSFCVFKFMALYSIIQCLSVALLYSIGSNLGDFQFLFIDMAIILLIVFTMSLNSA 992

  Fly  1218 FDGMLVEQVPLSSLISSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGC----- 1277
            :. .||.:.|.|.|:|...|.|:|..:.:..|||:..::.:.:..|:     :..|...|
Zfish   993 WK-ELVARRPPSGLVSGPLLFSVLTQILICLAFQIIAFLLIQRLDWY-----SKPDFYNCSLPHH 1051

  Fly  1278 FENY-----------------TMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCII 1325
            ..||                 |:|.||||||:|:|.|||||.|:|:|.:.|||..|:.::.:..:
Zfish  1052 MNNYSNSTGTKEENIVNDVNTTLFFISSFQYLIVAIVFSKGKPFRQPSYKNWPFVLSALILVIFM 1116

  Fly  1326 VYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVE-------SFLVEYLVFKKYQV 1383
            .:::.:|...:..|.:|:..| :.:|..|:....|:.|..:.:|       |..:.:|..::.:|
Zfish  1117 FFIMFFPISGIYKFLELVCVP-LSWRVSMVIIILANTIVSVIIEGGIDMYGSKCLSWLCCRRRKV 1180

  Fly  1384 KREKNWVTSKQKYMRLEHDISNIKNWPP----ITEVYEPNNLIDC 1424
                    .|.:||.|..::|...:|||    .||.....:..||
Zfish  1181 --------PKARYMHLAQELSVDPDWPPKPKSTTEAKPALHPDDC 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194	37/140 (26%)
		P-ATPase-V	173..1355	CDD:273738	491/1238 (40%)
		E1-E2_ATPase	381..621	CDD:278548	130/250 (52%)
		Cation_ATPase	<758..813	CDD:289987	25/65 (38%)
		HAD_like	<1087..1137	CDD:304363	37/49 (76%)
atp13a3	XP_009304446.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820